The immune response to Giardia.

The flagellate Giardia duodenalis has been considered for many years to be a commensal living in the lumen of the small intestine of its host. It is only 25 years ago that it was accepted that Giardia is a significant pathogen of humans. Knowledge that Giardia can elicit an immune response that would probably contribute to the onset or absence of symptoms is not much older. The use of animal models to study the disease in the laboratory, together with the production of the whole life cycle in a test tube, have contributed greatly to our present knowledge of the immune responses to Giardia and of antigens that are specific to the trophozoite or cyst stages. In this review, Gaétan Faubert focuses on studies published since the last review in Parasitology Today in 1988, and examines the roles played by the humoral and cell-mediated immune responses in the control of the infection. It also covers the immunodiagnostic assays that have been recently developed on the basis of advances in our knowledge of the antigens of Giardia.