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Literature DB >> 15273144

Rv2686c-Rv2687c-Rv2688c, an ABC fluoroquinolone efflux pump in Mycobacterium tuberculosis.

Maria Rosalia Pasca¹, Paola Guglierame, Fabio Arcesi, Marco Bellinzoni, Edda De Rossi, Giovanna Riccardi.

Abstract

The Mycobacterium tuberculosis Rv2686c-Rv2687c-Rv2688c operon, encoding an ABC transporter, conferred resistance to ciprofloxacin and, to a lesser extent, norfloxacin, moxifloxacin, and sparfloxacin to Mycobacterium smegmatis. The resistance level decreased in the presence of the efflux pump inhibitors reserpine, carbonyl cyanide m-chlorophenylhydrazone, and verapamil. Energy-dependent efflux of ciprofloxacin from M. smegmatis cells containing the Rv2686c-Rv2687c-Rv2688c operon was observed.

Entities: Chemical Species

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Year: 2004 PMID： 15273144 PMCID： PMC478549 DOI： 10.1128/AAC.48.8.3175-3178.2004

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

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