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Literature DB >> 18541729

Identification of mutations related to streptomycin resistance in clinical isolates of Mycobacterium tuberculosis and possible involvement of efflux mechanism.

Fernanda S Spies¹, Pedro E Almeida da Silva, Marta O Ribeiro, Maria Lucia Rossetti, Arnaldo Zaha.

Abstract

The MIC for streptomycin in the presence of efflux pump (EP) inhibitors and the sequencing of rpsL, rrs, and gidB genes provided evidence for the possible participation of EP in low-level streptomycin (STR) resistance of some isolates without mutations. Mutation in the gidB gene and an EP could act synergistically to confer low STR resistance.

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Year: 2008 PMID： 18541729 PMCID： PMC2493096 DOI： 10.1128/AAC.01570-07

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

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