Literature DB >> 15250722

The dynamic character of the G-quadruplex element in the c-MYC promoter and modification by TMPyP4.

Jeyaprakashnarayanan Seenisamy1, Evonne M Rezler, Tiffanie J Powell, Denise Tye, Vijay Gokhale, Chandana Sharma Joshi, Adam Siddiqui-Jain, Laurence H Hurley.   

Abstract

The nuclease hypersensitivity element III1 (NHE III1) upstream of the P1 and P2 promoters of c-MYC controls 80-90% of the transcriptional activity of this gene. The purine-rich strand in this region can form a G-quadruplex structure that is a critical part of the silencer element for this promoter. We have demonstrated that this G-quadruplex structure can form a mixture of four biologically relevant parallel-loop isomers, which upon interaction with the cationic porphyrin TMPyP4 are converted to mixed parallel/antiparallel G-quadruplex structures.

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Year:  2004        PMID： 15250722     DOI： 10.1021/ja040022b

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  132 in total

1.  Engineering the quadruplex fold: nucleoside conformation determines both folding topology and molecularity in guanine quadruplexes.

Authors:  Chung-Fei Tang; Richard H Shafer
Journal:  J Am Chem Soc       Date:  2006-05-03       Impact factor: 15.419

2.  Solution structure of a 2:1 quindoline-c-MYC G-quadruplex: insights into G-quadruplex-interactive small molecule drug design.

Authors:  Jixun Dai; Megan Carver; Laurence H Hurley; Danzhou Yang
Journal:  J Am Chem Soc       Date:  2011-10-14       Impact factor: 15.419

3.  Molecular cloning of the human platelet-derived growth factor receptor beta (PDGFR-beta) promoter and drug targeting of the G-quadruplex-forming region to repress PDGFR-beta expression.

Authors:  Yong Qin; Jessica S Fortin; Denise Tye; Mary Gleason-Guzman; Tracy A Brooks; Laurence H Hurley
Journal:  Biochemistry       Date:  2010-05-18       Impact factor: 3.162

4.  Formation of pseudosymmetrical G-quadruplex and i-motif structures in the proximal promoter region of the RET oncogene.

Authors:  Kexiao Guo; Alan Pourpak; Kara Beetz-Rogers; Vijay Gokhale; Daekyu Sun; Laurence H Hurley
Journal:  J Am Chem Soc       Date:  2007-08-02       Impact factor: 15.419

5.  Deconvoluting the structural and drug-recognition complexity of the G-quadruplex-forming region upstream of the bcl-2 P1 promoter.

Authors:  Thomas S Dexheimer; Daekyu Sun; Laurence H Hurley
Journal:  J Am Chem Soc       Date:  2006-04-26       Impact factor: 15.419

Review 6.  DNA architecture: from G to Z.

Authors:  Anh Tuân Phan; Vitaly Kuryavyi; Dinshaw J Patel
Journal:  Curr Opin Struct Biol       Date:  2006-05-22       Impact factor: 6.809

7.  An intramolecular G-quadruplex structure with mixed parallel/antiparallel G-strands formed in the human BCL-2 promoter region in solution.

Authors:  Jixun Dai; Thomas S Dexheimer; Ding Chen; Megan Carver; Attila Ambrus; Roger A Jones; Danzhou Yang
Journal:  J Am Chem Soc       Date:  2006-02-01       Impact factor: 15.419

8.  Genome-wide prediction of G4 DNA as regulatory motifs: role in Escherichia coli global regulation.

Authors:  Pooja Rawal; Veera Bhadra Rao Kummarasetti; Jinoy Ravindran; Nirmal Kumar; Kangkan Halder; Rakesh Sharma; Mitali Mukerji; Swapan Kumar Das; Shantanu Chowdhury
Journal:  Genome Res       Date:  2006-05       Impact factor: 9.043

Review 9.  The role of supercoiling in transcriptional control of MYC and its importance in molecular therapeutics.

Authors:  Tracy A Brooks; Laurence H Hurley
Journal:  Nat Rev Cancer       Date:  2009-11-12       Impact factor: 60.716

10.  The i-motif in the bcl-2 P1 promoter forms an unexpectedly stable structure with a unique 8:5:7 loop folding pattern.

Authors:  Samantha Kendrick; Yoshitsugu Akiyama; Sidney M Hecht; Laurence H Hurley
Journal:  J Am Chem Soc       Date:  2009-12-09       Impact factor: 15.419
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