Literature DB >> 15249552

Joining mutants of RAG1 and RAG2 that demonstrate impaired interactions with the coding-end DNA.

Fumikiyo Nagawa1, Satoshi Hirose, Hirofumi Nishizumi, Tadashi Nishihara, Hitoshi Sakano.   

Abstract

In V(D)J joining of antigen receptor genes, two recombination signal sequences (RSSs), 12- and 23-RSSs, form a complex with the protein products of recombination activating genes, RAG1 and RAG2. DNaseI footprinting demonstrates that the interaction of RAG proteins with substrate RSS DNA is not just limited to the signal region but involves the coding sequence as well. Joining mutants of RAG1 and RAG2 demonstrate impaired interactions with the coding region in both pre- and postcleavage type complexes. A possible role of this RAG coding region interaction is discussed in the context of V(D)J recombination.

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Year:  2004        PMID： 15249552     DOI： 10.1074/jbc.M405485200

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  14 in total

1.  Increased frequency of aberrant V(D)J recombination products in core RAG-expressing mice.

Authors:  Sadiqur R Talukder; Darryll D Dudley; Frederick W Alt; Yousuke Takahama; Yoshiko Akamatsu
Journal:  Nucleic Acids Res       Date:  2004-08-24       Impact factor: 16.971

2.  Synapsis alters RAG-mediated nicking at Tcrb recombination signal sequences: implications for the “beyond 12/23” rule.

Authors:  Joydeep K Banerjee; David G Schatz
Journal:  Mol Cell Biol       Date:  2014-07       Impact factor: 4.272

3.  Hereditary pituitary hyperplasia with infantile gigantism.

Authors:  Sven Gläsker; Alexander O Vortmeyer; Antony R A Lafferty; Paul L Hofman; Jie Li; Robert J Weil; Zhengping Zhuang; Edward H Oldfield
Journal:  J Clin Endocrinol Metab       Date:  2011-10-05       Impact factor: 5.958

Review 4.  The origins of the Rag genes--from transposition to V(D)J recombination.

Authors:  Sebastian D Fugmann
Journal:  Semin Immunol       Date:  2009-12-09       Impact factor: 11.130

5.  Fluorescence resonance energy transfer analysis of recombination signal sequence configuration in the RAG1/2 synaptic complex.

Authors:  Mihai Ciubotaru; Aleksei N Kriatchko; Patrick C Swanson; Frank V Bright; David G Schatz
Journal:  Mol Cell Biol       Date:  2007-04-30       Impact factor: 4.272

6.  Leaky severe combined immunodeficiency and aberrant DNA rearrangements due to a hypomorphic RAG1 mutation.

Authors:  William Giblin; Monalisa Chatterji; Gerwin Westfield; Tehmina Masud; Brian Theisen; Hwei-Ling Cheng; Jeffrey DeVido; Frederick W Alt; David O Ferguson; David G Schatz; JoAnn Sekiguchi
Journal:  Blood       Date:  2009-01-06       Impact factor: 22.113

7.  The beyond 12/23 restriction is imposed at the nicking and pairing steps of DNA cleavage during V(D)J recombination.

Authors:  Anna H Drejer-Teel; Sebastian D Fugmann; David G Schatz
Journal:  Mol Cell Biol       Date:  2007-07-16       Impact factor: 4.272

8.  H3K4me3 stimulates the V(D)J RAG complex for both nicking and hairpinning in trans in addition to tethering in cis: implications for translocations.

Authors:  Noriko Shimazaki; Albert G Tsai; Michael R Lieber
Journal:  Mol Cell       Date:  2009-06-12       Impact factor: 17.970

9.  Real-time monitoring of RAG-catalyzed DNA cleavage unveils dynamic changes in coding end association with the coding end complex.

Authors:  Guannan Wang; Kajari Dhar; Patrick C Swanson; Marcia Levitus; Yung Chang
Journal:  Nucleic Acids Res       Date:  2012-03-20       Impact factor: 16.971

10.  Initiation of V(D)J recombination by Dbeta-associated recombination signal sequences: a critical control point in TCRbeta gene assembly.

Authors:  Don-Marc Franchini; Touati Benoukraf; Sébastien Jaeger; Pierre Ferrier; Dominique Payet-Bornet
Journal:  PLoS One       Date:  2009-02-24       Impact factor: 3.240
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