| Literature DB >> 15246663 |
Seung Pil Pack1, Young Je Yoo.
Abstract
Structural distributions of each amino acid were compared between 20 pairs of thermophilic and mesophilic proteins to obtain thermostable factors. Five kinds of residual structure states such as fully-exposed, exposed, partially exposed (or partially buried), buried, well-buried states were considered for analyzing the structural patterns of amino acids. The statistical tests revealed that lower frequency in partially exposed state of SER, lower frequency in exposed state and higher frequency in well-buried state of ALA, higher frequency in buried state of GLU, higher frequency in exposed state of ARG, etc. could be critical factors related with protein thermostability.Entities:
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Year: 2004 PMID： 15246663 DOI： 10.1016/j.jbiotec.2004.01.018
Source DB: PubMed Journal: J Biotechnol ISSN： 0168-1656 Impact factor: 3.307