T Mak1, F Lalloo, D G R Evans, J Hill. 1. Department of General Surgery, Manchester Royal Infirmary, Manchester, UK. Tonymak2000@hotmail.com
Abstract
BACKGROUND: Mass screening for colorectal cancer reduces mortality and, with recent advances in molecular genetics, molecular stool-based tests have produced promising results. This article reviews this innovation and discusses its clinical significance. METHODS: Medline searches were used to identify recent key articles relating to stool-based testing. Further articles were obtained by manual scanning of the reference lists of identified papers. RESULTS: Current screening methods are based on endoscopic, radiological and stool-based testing. Recent recognition of the adenoma-carcinoma sequence and pathophysiological studies of colonic epithelium have enabled tumour markers to be used in the screening setting. Non-invasive molecular stool testing has now been shown to have a high sensitivity and specificity. CONCLUSION: Recent studies on molecular stool-based testing have shown higher sensitivity and specificity than earlier studies, but larger clinical trials are required. Laboratory methods are still undergoing research, with the aim of improving sensitivity to allow large-scale testing. Copyright 2004 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
BACKGROUND: Mass screening for colorectal cancer reduces mortality and, with recent advances in molecular genetics, molecular stool-based tests have produced promising results. This article reviews this innovation and discusses its clinical significance. METHODS: Medline searches were used to identify recent key articles relating to stool-based testing. Further articles were obtained by manual scanning of the reference lists of identified papers. RESULTS: Current screening methods are based on endoscopic, radiological and stool-based testing. Recent recognition of the adenoma-carcinoma sequence and pathophysiological studies of colonic epithelium have enabled tumour markers to be used in the screening setting. Non-invasive molecular stool testing has now been shown to have a high sensitivity and specificity. CONCLUSION: Recent studies on molecular stool-based testing have shown higher sensitivity and specificity than earlier studies, but larger clinical trials are required. Laboratory methods are still undergoing research, with the aim of improving sensitivity to allow large-scale testing. Copyright 2004 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
Authors: Jens K Habermann; Uwe J Roblick; Brian T Luke; Darue A Prieto; William J J Finlay; Vladimir N Podust; John M Roman; Elisabeth Oevermann; Thomas Schiedeck; Nils Homann; Michael Duchrow; Thomas P Conrads; Timothy D Veenstra; Stanley K Burt; Hans-Peter Bruch; Gert Auer; Thomas Ried Journal: Gastroenterology Date: 2006-10 Impact factor: 22.682
Authors: Melissa C Kordahi; Ian B Stanaway; Marion Avril; Denise Chac; Marie-Pierre Blanc; Benjamin Ross; Christian Diener; Sumita Jain; Paul McCleary; Ana Parker; Vincent Friedman; Jennifer Huang; Wynn Burke; Sean M Gibbons; Amy D Willis; Richard P Darveau; William M Grady; Cynthia W Ko; R William DePaolo Journal: Cell Host Microbe Date: 2021-09-17 Impact factor: 31.316
Authors: Jens K Habermann; Franz G Bader; Christian Franke; Kaja Zimmermann; Timo Gemoll; Britta Fritzsche; Thomas Ried; Gert Auer; Hans-Peter Bruch; Uwe J Roblick Journal: Langenbecks Arch Surg Date: 2007-10-16 Impact factor: 3.445