| Literature DB >> 29935904 |
Colleen S Curran1, Elad Sharon2.
Abstract
Disruption of liver immune tolerance allows for the development of autoimmune hepatitis (AIH) and hepatocellular carcinoma (HCC). AIH rarely progresses to HCC but the diseases similarly induce the production of IL-18 and matrix metalloproteinases. These molecules have distinct effects on the immune response, including the programmed cell-death 1 (PD-1) axis. In this review, differences in PD-1 function and possible cell signals in AIH and HCC are highlighted. Published by Elsevier Inc.Entities:
Keywords: IL-18; autoimmune hepatitis; hepatocellular carcinoma; matrix metalloproteinases; programmed cell-death 1 (PD-1)
Mesh:
Substances:
Year: 2018 PMID: 29935904 PMCID: PMC6086388 DOI: 10.1053/j.seminoncol.2017.12.001
Source DB: PubMed Journal: Semin Oncol ISSN: 0093-7754 Impact factor: 4.929