| Literature DB >> 15194493 |
Yuki Sato1, Hitoshi Endo, Takashi Ajiki, Yoji Hakamata, Takashi Okada, Takashi Murakami, Eiji Kobayashi.
Abstract
The rat has offered an important animal model in biomedical research including surgical procedure. However, advanced genetic manipulation has progressed less far in the rat than in the mouse. Here we report the Cre/LoxP transgenic rat system, demonstrating conditional chromosomal translocation both in the fertilization and adult stage, spatio-temporal gene controlling by catheter-based adenoviral gene transfer, and muscular fusion events in the limb transplant. Taking advantage of the larger body size of the rat than the mouse, this rat system provides a potential value to evaluate biomedical and therapeutic significance for gene therapy and regenerative medicine.Entities:
Mesh：
Year: 2004 PMID： 15194493 DOI： 10.1016/j.bbrc.2004.04.204
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575