STUDY OBJECTIVES: Obstructive sleep apnea (OSA) is associated with nocturnal angina and ST-segment depression, which are relieved by treatment with continuous positive airway pressure (CPAP). We tested the hypothesis that severe nocturnal hypoxia in patients with OSA causes myocyte necrosis as evidenced by increases in cardiac troponin T. DESIGN: Prospective cohort study. SETTING: Cardiovascular physiology and sleep research laboratory. PARTICIPANTS: Fifteen male volunteers with coronary artery disease (CAD) and moderate or severe OSA (apnea-hypopnea index [AHI] > 15). MEASUREMENTS AND RESULTS: Polysomnography and measurement of serum cardiac troponin T before sleep, after 4 h of untreated OSA, and in the morning after 4 h of treatment with CPAP. The mean AHI for the group was 41 (SD 16), and the mean oxygen saturation nadir during sleep was 83% (SD 8%). All measurements of cardiac troponin T were < 0.010 ng/mL. CONCLUSIONS: Despite the fact that some patients with OSA may experience nocturnal ischemia, this study shows that patients with severe OSA and coexisting CAD do not have nightly episodes of myocardial injury detectable by the current-generation cardiac troponin T assay.
STUDY OBJECTIVES:Obstructive sleep apnea (OSA) is associated with nocturnal angina and ST-segment depression, which are relieved by treatment with continuous positive airway pressure (CPAP). We tested the hypothesis that severe nocturnal hypoxia in patients with OSA causes myocyte necrosis as evidenced by increases in cardiac troponin T. DESIGN: Prospective cohort study. SETTING: Cardiovascular physiology and sleep research laboratory. PARTICIPANTS: Fifteen male volunteers with coronary artery disease (CAD) and moderate or severe OSA (apnea-hypopnea index [AHI] > 15). MEASUREMENTS AND RESULTS: Polysomnography and measurement of serum cardiac troponin T before sleep, after 4 h of untreated OSA, and in the morning after 4 h of treatment with CPAP. The mean AHI for the group was 41 (SD 16), and the mean oxygen saturation nadir during sleep was 83% (SD 8%). All measurements of cardiac troponin T were < 0.010 ng/mL. CONCLUSIONS: Despite the fact that some patients with OSA may experience nocturnal ischemia, this study shows that patients with severe OSA and coexisting CAD do not have nightly episodes of myocardial injury detectable by the current-generation cardiac troponin T assay.
Authors: M Melanie Lyons; Nitin Y Bhatt; Elizabeth Kneeland-Szanto; Brendan T Keenan; Joanne Pechar; Branden Stearns; Nabil M Elkassabany; Stavros G Memtsoudis; Allan I Pack; Indira Gurubhagavatula Journal: Biomark Med Date: 2016 Impact factor: 2.851
Authors: Gabriela Querejeta Roca; Susan Redline; Naresh Punjabi; Brian Claggett; Christie M Ballantyne; Scott D Solomon; Amil M Shah Journal: Am J Respir Crit Care Med Date: 2013-12-15 Impact factor: 21.405
Authors: Gunnar Einvik; Helge Røsjø; Anna Randby; Silje K Namtvedt; Harald Hrubos-Strøm; Jon Brynildsen; Virend K Somers; Torbjørn Omland Journal: Sleep Date: 2014-06-01 Impact factor: 5.849
Authors: Fernando De Torres-Alba; Daniele Gemma; Eduardo Armada-Romero; Juan Ramón Rey-Blas; Esteban López-de-Sá; José Luis López-Sendon Journal: Pulm Med Date: 2013-04-15