BACKGROUND: Suicide and suicidal behavior are prevalent among individuals with psychiatric disorders, including alcohol dependence. A genome screen was performed in multiplex alcohol dependent families ascertained as part of the Collaborative Study on the Genetics of Alcoholism to identify chromosomal regions of interest related to two types of suicidal behavior: suicide attempts and suicidality. METHODS: Sibling pair analyses were used to conduct linkage analyses using both qualitative and quantitative suicide-related phenotypes. The qualitative trait of "suicide attempts" was examined using 59 affected sibling pairs. The quantitative trait of "suicidality" was examined using all possible 1366 sibling pairs and 705 independent sibling pairs. RESULTS: For the qualitative phenotype suicide attempts, chromosome 2 yielded a maximum lod score of 4.2. For the quantitative suicidality index, a maximum lod score of 1.8 was observed on chromosome 3, and a lod score of 1.5 was found on chromosome 1. CONCLUSIONS: This study represents the first genome-wide scan of suicidal behavior. Significant evidence of linkage was found on chromosome 2 for the phenotype suicide attempts, the same chromosomal region previously reported to be linked to alcohol dependence in this sample. This finding does not seem to be due solely to an association between suicide and alcohol dependence. There was more modest evidence of linkage to chromosomes 1 and 3 for suicidality; however, these findings did not reach statistical significance. There was no overlap in findings for these two phenotypes of suicidal behavior.
BACKGROUND: Suicide and suicidal behavior are prevalent among individuals with psychiatric disorders, including alcohol dependence. A genome screen was performed in multiplex alcohol dependent families ascertained as part of the Collaborative Study on the Genetics of Alcoholism to identify chromosomal regions of interest related to two types of suicidal behavior: suicide attempts and suicidality. METHODS: Sibling pair analyses were used to conduct linkage analyses using both qualitative and quantitative suicide-related phenotypes. The qualitative trait of "suicide attempts" was examined using 59 affected sibling pairs. The quantitative trait of "suicidality" was examined using all possible 1366 sibling pairs and 705 independent sibling pairs. RESULTS: For the qualitative phenotype suicide attempts, chromosome 2 yielded a maximum lod score of 4.2. For the quantitative suicidality index, a maximum lod score of 1.8 was observed on chromosome 3, and a lod score of 1.5 was found on chromosome 1. CONCLUSIONS: This study represents the first genome-wide scan of suicidal behavior. Significant evidence of linkage was found on chromosome 2 for the phenotype suicide attempts, the same chromosomal region previously reported to be linked to alcohol dependence in this sample. This finding does not seem to be due solely to an association between suicide and alcohol dependence. There was more modest evidence of linkage to chromosomes 1 and 3 for suicidality; however, these findings did not reach statistical significance. There was no overlap in findings for these two phenotypes of suicidal behavior.
Authors: Sophia C Gaynor; Marie E Breen; Eric T Monson; Kelly de Klerk; Meredith Parsons; Adam P DeLuca; Todd E Scheetz; Peter P Zandi; James B Potash; Virginia L Willour Journal: Am J Med Genet B Neuropsychiatr Genet Date: 2016-08-02 Impact factor: 3.568
Authors: Eric T Monson; Mehdi Pirooznia; Jennifer Parla; Melissa Kramer; Fernando S Goes; Marie E Gaine; Sophia C Gaynor; Kelly de Klerk; Dubravka Jancic; Rachel Karchin; W Richard McCombie; Peter P Zandi; James B Potash; Virginia L Willour Journal: Mol Neuropsychiatry Date: 2017-01-18
Authors: Danielle M Dick; Jacquelyn Meyers; Fazil Aliev; John Nurnberger; John Kramer; Sam Kuperman; Bernice Porjesz; Jay Tischfield; Howard J Edenberg; Tatiana Foroud; Marc Schuckit; Alison Goate; Victor Hesselbrock; Laura Bierut Journal: Am J Med Genet B Neuropsychiatr Genet Date: 2010-09 Impact factor: 3.568
Authors: Pamela B Mahon; Adrian M Stütz; Fayaz Seifuddin; Yuqing Huo; Fernando S Goes; Dubravka Jancic; Jennifer T Judy; J Raymond Depaulo; Elliot S Gershon; Francis J McMahon; Peter P Zandi; James B Potash; Virginia L Willour Journal: Am J Med Genet B Neuropsychiatr Genet Date: 2010-07 Impact factor: 3.568
Authors: Arpana Agrawal; Anthony L Hinrichs; Gerald Dunn; Sarah Bertelsen; Danielle M Dick; Scott F Saccone; Nancy L Saccone; Richard A Grucza; Jen C Wang; C Robert Cloninger; Howard J Edenberg; Tatiana Foroud; Victor Hesselbrock; John Kramer; Kathleen K Bucholz; Samuel Kuperman; John I Nurnberger; Bernice Porjesz; Marc A Schuckit; Alison M Goate; Laura J Bierut Journal: Drug Alcohol Depend Date: 2007-10-17 Impact factor: 4.492
Authors: D F Levey; E M Niculescu; H Le-Niculescu; H L Dainton; P L Phalen; T B Ladd; H Weber; E Belanger; D L Graham; F N Khan; N P Vanipenta; E C Stage; A Ballew; M Yard; T Gelbart; A Shekhar; N J Schork; S M Kurian; G E Sandusky; D R Salomon; A B Niculescu Journal: Mol Psychiatry Date: 2016-04-05 Impact factor: 15.992
Authors: Eva Lindholm Carlström; Peter Saetre; Anders Rosengren; Johan H Thygesen; Srdjan Djurovic; Ingrid Melle; Ole A Andreassen; Thomas Werge; Ingrid Agartz; Håkan Hall; Lars Terenius; Erik G Jönsson Journal: Behav Brain Funct Date: 2012-05-17 Impact factor: 3.759