| Literature DB >> 15165891 |
Ricardo Flores1, Sonia Delgado, María-Eugenia Gas, Alberto Carbonell, Diego Molina, Selma Gago, Marcos De la Peña.
Abstract
Viroids are small (246-401 nucleotides), non-coding, circular RNAs able to replicate autonomously in certain plants. Viroids are classified into the families Pospiviroidae and Avsunviroidae, whose members replicate in the nucleus and chloroplast, respectively. Replication occurs by an RNA-based rolling-circle mechanism in three steps: (1). synthesis of longer-than-unit strands catalyzed by host DNA-dependent RNA polymerases forced to transcribe RNA templates, (2). processing to unit-length, which in family Avsunviroidae is mediated by hammerhead ribozymes, and (3). circularization either through an RNA ligase or autocatalytically. Disease induction might result from the accumulation of viroid-specific small interfering RNAs that, via RNA silencing, could interfere with normal developmental pathways.Mesh：
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Year: 2004 PMID： 15165891 DOI： 10.1016/j.febslet.2004.03.118
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124