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Literature DB >> 16321003

Synthesis of antimicrobial natural products targeting FtsZ: (+/-)-dichamanetin and (+/-)-2' ''-hydroxy-5' '-benzylisouvarinol-B.

Sameer Urgaonkar¹, Henry S La Pierre, Israel Meir, Henrik Lund, Debabrata RayChaudhuri, Jared T Shaw.

Abstract

[chemical structure: see text]. Two natural products have been synthesized using a ZnCl2-mediated benzylic coupling reaction. Both are potent inhibitors of the GTPase activity of FtsZ, a highly conserved protein that is essential for bacterial cytokinesis.

Entities: Chemical

Mesh：

Substances：

Year: 2005 PMID： 16321003 PMCID： PMC2588422 DOI： 10.1021/ol052269z

Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005

16 in total

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Review 2. Bacterial division: the fellowship of the ring.

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Review 7. Cytokinesis in bacteria.

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9. 2-Alkoxycarbonylaminopyridines: inhibitors of Mycobacterium tuberculosis FtsZ.

Authors: E Lucile White; William J Suling; Larry J Ross; Lainne E Seitz; Robert C Reynolds
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Review 10. Assembly dynamics of the bacterial cell division protein FTSZ: poised at the edge of stability.

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33 in total

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2. Practical synthesis of PC190723, an inhibitor of the bacterial cell division protein FtsZ.

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Review 4. Challenges of antibacterial discovery.

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6. Enterococcal and streptococcal resistance to PC190723 and related compounds: molecular insights from a FtsZ mutational analysis.

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