Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Lung tumorigenesis by 1,2-diformylhydrazine in mice.

Literature DB >> 151401

Lung tumorigenesis by 1,2-diformylhydrazine in mice.

Abstract

1,2-Diformylhydrazine was administered in drinking water as a 2% solution to randomly bred Swiss albino mice for life from 6 weeks of age. As a result of treatment, the lung tumor incidence rose from 15 to 96% in females and from 22 to 82% in males. The treatment had no statistically significant effect on the development of other types of tumors. Histopathologically, the neoplasms exhibited the characteristic appearance of adenomas and adenocarcinomas of the lungs. The work is part of a series of studies aimed at revealing the relative carcinogenic potency of mono- and dialkyl-hydrazines and also their possible environmental significance as cancer causative agents.

Entities: Chemical Disease Species

Mesh：

Substances：
Hydrazines

Year: 1978 PMID： 151401 DOI： 10.1007/bf00284090

Source DB: PubMed Journal: Z Krebsforsch Klin Onkol Cancer Res Clin Oncol ISSN： 0084-5353

14 in total

Review 1. Naturally occurring compounds Containing a nitrogen-nitrogen bond.

Authors: T A LaRue
Journal: Lloydia Date: 1977 Jul-Aug

2. A new antibiotic XK-90 I. Taxonomy of the producing organism, fermentation, isolation and physicochemical and biological properties.

Authors: S Takasawa; M Yamamoto; R Okachi; I Kawamoto; S Sato; T Nara
Journal: J Antibiot (Tokyo) Date: 1976-10 Impact factor: 2.649

3. 1-Carbamyl-2-phenylhydrazine tumorigenesis in Swiss mice. Morphology of lung adenomas.

Authors: B Toth; H Shimizu
Journal: J Natl Cancer Inst Date: 1974-01 Impact factor: 13.506

4. 1,1-Dimethylhydrazine (unsymmetrical) carcinogenesis in mice. Light microscopic and ultrastructural studies on neoplastic blood vessels.

Authors: B Toth
Journal: J Natl Cancer Inst Date: 1973-01 Impact factor: 13.506

4. Genotoxicity of a variety of hydrazine derivatives in the hepatocyte primary culture/DNA repair test using rat and mouse hepatocytes.

Authors: H Mori; S Sugie; N Yoshimi; H Iwata; A Nishikawa; K Matsukubo; H Shimizu; I Hirono
Journal: Jpn J Cancer Res Date: 1988-02

4 in total

Lung tumorigenesis by 1,2-diformylhydrazine in mice.

Review 1. Naturally occurring compounds Containing a nitrogen-nitrogen bond.

2. A new antibiotic XK-90 I. Taxonomy of the producing organism, fermentation, isolation and physicochemical and biological properties.

3. 1-Carbamyl-2-phenylhydrazine tumorigenesis in Swiss mice. Morphology of lung adenomas.

4. 1,1-Dimethylhydrazine (unsymmetrical) carcinogenesis in mice. Light microscopic and ultrastructural studies on neoplastic blood vessels.

5. Chemical studies on tobacco smoke. Quantitative analysis of hydrazine in tobacco and cigarette smoke.

6. Negamycin, a novel hydrazide antibiotic.

7. [Gyromitrin, the poison of Gyromitra esculenta. 16. On the fungi contents].

8. Tumorigenicity of tetramethylhydrazine hydrochloride in Swiss mice.

9. Synthetic and naturally occurring hydrazines as possible cancer causative agents.

10. Formylhydrazine carcinogenesis in mice.

1. 1,2-di-n-butylhydrazine dihydrochloride carcinogenesis in mice.

2. Actual new cancer-causing hydrazines, hydrazides, and hydrazones.

3. A carcinogenic potency database of the standardized results of animal bioassays.

4. Genotoxicity of a variety of hydrazine derivatives in the hepatocyte primary culture/DNA repair test using rat and mouse hepatocytes.