Literature DB >> 7462301

Actual new cancer-causing hydrazines, hydrazides, and hydrazones.

B Toth.   

Abstract

Twenty actual new cancer-causing hydrazines, hydrazides, and hydrazones of synthetic or natural origin are described. These compounds induce tumors in various target tissues in mice, hamsters and rats. To nine of these compounds the human population is exposed in the form of drugs, agricultural herbicides, and naturally occurring ingredients of edible mushrooms. Yet, with one exception, none of the hydrazines described here were investigated for cancer-inducing abilities in man. The human population should be warned against the use of this hazardous class of chemicals, the total number of which is now 40.

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Year:  1980        PMID： 7462301     DOI： 10.1007/bf00409895

Source DB:  PubMed          Journal:  J Cancer Res Clin Oncol        ISSN： 0171-5216            Impact factor:   4.553


  47 in total

Review 1.  Naturally occurring compounds Containing a nitrogen-nitrogen bond.

Authors:  T A LaRue
Journal:  Lloydia       Date:  1977 Jul-Aug

2.  A new antibiotic XK-90 I. Taxonomy of the producing organism, fermentation, isolation and physicochemical and biological properties.

Authors:  S Takasawa; M Yamamoto; R Okachi; I Kawamoto; S Sato; T Nara
Journal:  J Antibiot (Tokyo)       Date:  1976-10       Impact factor: 2.649

3.  Carcinogenicity of formic acid 2-[4-(5-nitro-2-furyl)-2-thiazolyl]-hydrazide in Swiss mice.

Authors:  S M Cohen; E Ertürk; G T Bryan
Journal:  Cancer Res       Date:  1970-04       Impact factor: 12.701

Review 4.  Metabolic fate of hydrazines and hydrazides.

Authors:  L B Colvin
Journal:  J Pharm Sci       Date:  1969-12       Impact factor: 3.534

5.  Hepatic carcinogenesis in CBA-Cb-Se mice and Cb-Se rats by isonicotinic acid hydrazide and hydrazine sulfate.

Authors:  L Severi; C Biancifiori
Journal:  J Natl Cancer Inst       Date:  1968-08       Impact factor: 13.506

6.  A new antibiotic, negamycin.

Authors:  M Hamada; T Takeuchi; S Kondo; Y Ikeda; H Naganawa
Journal:  J Antibiot (Tokyo)       Date:  1970-03       Impact factor: 2.649

7.  [Gyromitrin, the poison of Gyromitra esculenta. 16. On the fungi contents].

Authors:  P H List; P Luft
Journal:  Arch Pharm Ber Dtsch Pharm Ges       Date:  1968-04

8.  Tests for gyromitrin, a poisonous compound in false morel gyromitra esculenta.

Authors:  H Pyysalo
Journal:  Z Lebensm Unters Forsch       Date:  1976

9.  Tumor induction with the N'-acetyl derivative of 4-hydroxymethyl-phenylhydrazine, a metabolite of agaritine of Agaricus bisporus.

Authors:  B Toth; D Nagel; K Patil; J Erickson; K Antonson
Journal:  Cancer Res       Date:  1978-01       Impact factor: 12.701

10.  Induction of tumors in mice with the herbicide succinic acid 2,2-dimethylhydrazide.

Authors:  B Toth; L Wallcave; K Patil; I Schmeltz; D Hoffmann
Journal:  Cancer Res       Date:  1977-10       Impact factor: 12.701
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  9 in total

1.  The mutagenic mechanism of oxygenated alkylhydrazones occurs through alkyl radicals and alkyldiazonium ions.

Authors:  Keiko Inami; Miki Takada; Miho Nagata; Toshinori Higashi; Masataka Mochizuki
Journal:  Toxicol Res (Camb)       Date:  2017-02-02       Impact factor: 3.524

2.  Mutagenic and genotoxic activities of extracts derived from the cooked and raw edible mushroom Agaricus bisporus.

Authors:  B L Pool-Zobel; P Schmezer; Y Sinrachatanant; F Kaleagasioglu; K Reinhart; R Martin; P Klein; A R Tricker
Journal:  J Cancer Res Clin Oncol       Date:  1990       Impact factor: 4.553

3.  1,2-di-n-butylhydrazine dihydrochloride carcinogenesis in mice.

Authors:  B Toth; D Nagel
Journal:  Experientia       Date:  1981-07-15

4.  Carcinogenicity study in mice on pildralazine, a hydralazinelike antihypertensive compound.

Authors:  G Della Porta; T A Dragani
Journal:  J Cancer Res Clin Oncol       Date:  1983       Impact factor: 4.553

5.  Tumorigenicity of minute dose levels of N-methyl-N-formylhydrazine of Gyromitra esculenta.

Authors:  B Toth; K Patil
Journal:  Mycopathologia       Date:  1982-04-23       Impact factor: 2.574

6.  BIOTRANSFORMATION OF HYDRAZINE DERVATIVES IN THE MECHANISM OF TOXICITY.

Authors:  Birandra K Sinha; Ronald P Mason
Journal:  J Drug Metab Toxicol       Date:  2014-07-08

7.  DNA cleavage and detection of DNA radicals formed from hydralazine and copper (II) by ESR and immuno-spin trapping.

Authors:  Birandra K Sinha; Fabian Leinisch; Suchandra Bhattacharjee; Ronald P Mason
Journal:  Chem Res Toxicol       Date:  2014-02-13       Impact factor: 3.739

8.  Hemipiperazines as peptide-derived molecular photoswitches with low-nanomolar cytotoxicity.

Authors:  Susanne Kirchner; Anna-Lena Leistner; Peter Gödtel; Angelika Seliwjorstow; Sven Weber; Johannes Karcher; Martin Nieger; Zbigniew Pianowski
Journal:  Nat Commun       Date:  2022-10-14       Impact factor: 17.694

9.  Tumorigenesis by N-n-propyl-N-formylhydrazine in mice.

Authors:  B Toth; D Nagel; K Patil
Journal:  Br J Cancer       Date:  1980-12       Impact factor: 7.640
  9 in total

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