Literature DB >> 15137970

Comparison of different extraction methods for the determination of podophyllotoxin and 6-methoxypodophyllotoxin in Linum species.

Murat Kartal1, Belma Konuklugil, Gunawan Indrayanto, A W Alfermann.   

Abstract

Three extraction methods for analysis of podophyllotoxin and its derivatives from Linum species were compared. No statistical difference on the percentage of recovery were found between the methods. The "glycosidase-method" showed the best result with respect to the accuracy studies; the "acetone-method" has an advantage compared to the other methods due to its capability to calculate the aglycone, lignan glycoside and total lignan. The content of podophyllotoxin and 6-methoxypodophyllotoxin in Linum mucronatum subsp. mucronatum Bertol, Linum arboreum L., and the endemic Turkey species of Linum flavum subsp. scabrinerve Davis were determined. This is the first report on the analysis of podophyllotoxin and 6-methoxy podophyllotoxin of natural collected Linum flavum subsp. scabrinerve and Linum arboreum.

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Year:  2004        PMID： 15137970     DOI： 10.1016/j.jpba.2004.01.016

Source DB:  PubMed          Journal:  J Pharm Biomed Anal        ISSN： 0731-7085            Impact factor:   3.935


  8 in total

1.  Transcriptome-wide identification and characterization of CAD isoforms specific for podophyllotoxin biosynthesis from Podophyllum hexandrum.

Authors:  Dipto Bhattacharyya; Saptarshi Hazra; Anindyajit Banerjee; Riddhi Datta; Deepak Kumar; Saikat Chakrabarti; Sharmila Chattopadhyay
Journal:  Plant Mol Biol       Date:  2016-07-07       Impact factor: 4.076

2.  Induction of apoptosis in leukemia cell lines by Linum persicum and Euphorbia cheiradenia.

Authors:  Zahra Amirghofran; Masoud Bahmani; Abbas Azadmehr; Katayoun Javidnia
Journal:  J Cancer Res Clin Oncol       Date:  2006-02-14       Impact factor: 4.553

Review 3.  Podophyllotoxin: History, Recent Advances and Future Prospects.

Authors:  Zinnia Shah; Umar Farooq Gohar; Iffat Jamshed; Aamir Mushtaq; Hamid Mukhtar; Muhammad Zia-Ui-Haq; Sebastian Ionut Toma; Rosana Manea; Marius Moga; Bianca Popovici
Journal:  Biomolecules       Date:  2021-04-19

4.  Proteins differentially expressed in elicited cell suspension culture of Podophyllum hexandrum with enhanced podophyllotoxin content.

Authors:  Dipto Bhattacharyya; Ragini Sinha; Srijani Ghanta; Amrita Chakraborty; Saptarshi Hazra; Sharmila Chattopadhyay
Journal:  Proteome Sci       Date:  2012-05-23       Impact factor: 2.480

5.  Production of podophyllotoxin from roots and plantlets of Hyptis suaveolens cultivated in vitro.

Authors:  Rafael A Velóz; Alexandre Cardoso-Taketa; María Luisa Villarreal
Journal:  Pharmacognosy Res       Date:  2013-04

6.  6-Methoxy Podophyllotoxin Induces Apoptosis via Inhibition of TUBB3 and TOPIIA Gene Expressions in 5637 and K562 Cancer Cell Lines.

Authors:  Iman Sadeghi; Mehrdad Behmanesh; Najmeh Ahmadian Chashmi; Mohsen Sharifi; Bahram Mohammad Soltani
Journal:  Cell J       Date:  2015-10-07       Impact factor: 2.479

7.  Methyl Jasmonate Regulates Podophyllotoxin Accumulation in Podophyllum hexandrum by Altering the ROS-Responsive Podophyllotoxin Pathway Gene Expression Additionally through the Down Regulation of Few Interfering miRNAs.

Authors:  Saptarshi Hazra; Dipto Bhattacharyya; Sharmila Chattopadhyay
Journal:  Front Plant Sci       Date:  2017-02-14       Impact factor: 5.753

8.  De novo transcriptome analysis using 454 pyrosequencing of the Himalayan Mayapple, Podophyllum hexandrum.

Authors:  Dipto Bhattacharyya; Ragini Sinha; Saptarshi Hazra; Riddhi Datta; Sharmila Chattopadhyay
Journal:  BMC Genomics       Date:  2013-11-01       Impact factor: 3.969
  8 in total

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