| Literature DB >> 15133500 |
Yen-Ju Chen1, Peijun Zhang, Edward H Egelman, Jenny E Hinshaw.
Abstract
The GTPase dynamin is essential for numerous vesiculation events including clathrin-mediated endocytosis. Upon GTP hydrolysis, dynamin constricts a lipid bilayer. Previously, a three-dimensional structure of mutant dynamin in the constricted state was determined by helical reconstruction methods. We solved the nonconstricted state by a single-particle approach and show that the stalk region of dynamin undergoes a large conformational change that drives tube constriction.Entities:
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Year: 2004 PMID： 15133500 DOI： 10.1038/nsmb762
Source DB: PubMed Journal: Nat Struct Mol Biol ISSN： 1545-9985 Impact factor: 15.369