Literature DB >> 15132365

Drug-induced cardiac toxicity: emphasizing the role of electrocardiography in clinical research and drug development.

Ihor Gussak1, Jeffrey Litwin, Robert Kleiman, Scott Grisanti, Joel Morganroth.   

Abstract

This review describes the role of electrocardiography in clinical research and drug development, and addresses its utility in defining cardiac toxicity from noncardiac investigational drugs. Principles for designing electrocardiographic monitoring for cardiac safety in clinical trials are also reviewed.

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Year:  2004        PMID： 15132365     DOI： 10.1016/j.jelectrocard.2003.11.003

Source DB:  PubMed          Journal:  J Electrocardiol        ISSN： 0022-0736            Impact factor:   1.438


  7 in total

1.  Magnitude, mechanism, and reproducibility of QT interval differences between superimposed global and individual lead ECG complexes.

Authors:  Paul Kligfield; Benoit Tyl; Martine Maarek; Pierre Maison-Blanche
Journal:  Ann Noninvasive Electrocardiol       Date:  2007-04       Impact factor: 1.468

Review 2.  Cardiac applications for human pluripotent stem cells.

Authors:  Yuji Shiba; Kip D Hauch; Michael A Laflamme
Journal:  Curr Pharm Des       Date:  2009       Impact factor: 3.116

3.  Cardiac effects of echinocandins after central venous administration in adult rats.

Authors:  Christian Koch; Florian Uhle; Matthias Wolff; Christoph Arens; Astrid Schulte; Ling Li; Bernd Niemann; Michael Henrich; Susanne Rohrbach; Markus A Weigand; Christoph Lichtenstern
Journal:  Antimicrob Agents Chemother       Date:  2014-12-29       Impact factor: 5.191

Review 4.  How can we improve our understanding of cardiovascular safety liabilities to develop safer medicines?

Authors:  Hg Laverty; C Benson; Ej Cartwright; Mj Cross; C Garland; T Hammond; C Holloway; N McMahon; J Milligan; Bk Park; M Pirmohamed; C Pollard; J Radford; N Roome; P Sager; S Singh; T Suter; W Suter; A Trafford; Pga Volders; R Wallis; R Weaver; M York; Jp Valentin
Journal:  Br J Pharmacol       Date:  2011-06       Impact factor: 8.739

5.  Effect of trabectedin on the QT interval in patients with advanced solid tumor malignancies.

Authors:  R Thertulien; G M Manikhas; L Y Dirix; J B Vermorken; K Park; M M Jain; J J Jiao; J Natarajan; T Parekh; P Zannikos; A P Staddon
Journal:  Cancer Chemother Pharmacol       Date:  2011-07-08       Impact factor: 3.333

6.  Effect of single doses of IV palonosetron, up to 2.25 mg, on the QTc interval duration: a double-blind, randomized, parallel group study in healthy volunteers.

Authors:  Joel Morganroth; Kristen K Flaharty; Simona Parisi; Cecilia Moresino
Journal:  Support Care Cancer       Date:  2015-06-26       Impact factor: 3.603

7.  Effects of echinocandin preparations on adult rat ventricular cardiomyocytes. Preliminary results of an in vitro study.

Authors:  C Arens; F Uhle; M Wolff; R Röhrig; C Koch; A Schulte; S Weiterer; M Henrich; M A Weigand; K-D Schlüter; C Lichtenstern
Journal:  Anaesthesist       Date:  2014-02-07       Impact factor: 1.041
  7 in total

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