STUDY DESIGN: The authors report on anterior vertebral reconstruction following tumor resection with use of fresh-frozen, cortical, long-segment allografts prepared from diaphyseal sections of long bones. A retrospective analysis of clinical outcomes is presented. OBJECTIVE: To analyze the results following the use of cortical allografts in the treatment of spine tumors. SUMMARY OF BACKGROUND DATA: Metastatic disease and primary spinal bone tumors may result in progressive vertebral collapse, instability, deformity, pain, and neurologic deficit. Controversy as to the appropriate type of anterior reconstruction and/or graft material persists. METHODS: From 1995 until 2001, 30 patients with primary spinal bone tumors or metastases to the spine were treated by anterior vertebral reconstruction with fresh-frozen cortical bone allografts. Grafts were used in combination with anterior and posterior instrumentation. RESULTS: The median survival was 14 months. Ninety-three percent of all allografts were radiographically incorporated as early as 6 months after surgery in spite of adjuvant chemotherapy and radiation therapy. Fourteen patients (46%) had intraoperative or postoperative complications. Two patients underwent revision surgery for local recurrence. There were no allograft infections, fractures, or collapse. CONCLUSION: Anterior column reconstruction with structural cortical allografts proved to be a reliable technique in patients with spine tumors. Postoperative complications can often be successfully managed.
STUDY DESIGN: The authors report on anterior vertebral reconstruction following tumor resection with use of fresh-frozen, cortical, long-segment allografts prepared from diaphyseal sections of long bones. A retrospective analysis of clinical outcomes is presented. OBJECTIVE: To analyze the results following the use of cortical allografts in the treatment of spine tumors. SUMMARY OF BACKGROUND DATA: Metastatic disease and primary spinal bone tumors may result in progressive vertebral collapse, instability, deformity, pain, and neurologic deficit. Controversy as to the appropriate type of anterior reconstruction and/or graft material persists. METHODS: From 1995 until 2001, 30 patients with primary spinal bone tumors or metastases to the spine were treated by anterior vertebral reconstruction with fresh-frozen cortical bone allografts. Grafts were used in combination with anterior and posterior instrumentation. RESULTS: The median survival was 14 months. Ninety-three percent of all allografts were radiographically incorporated as early as 6 months after surgery in spite of adjuvant chemotherapy and radiation therapy. Fourteen patients (46%) had intraoperative or postoperative complications. Two patients underwent revision surgery for local recurrence. There were no allograft infections, fractures, or collapse. CONCLUSION: Anterior column reconstruction with structural cortical allografts proved to be a reliable technique in patients with spine tumors. Postoperative complications can often be successfully managed.
Authors: Thomas F DeLaney; Norbert J Liebsch; Francis X Pedlow; Judith Adams; Susan Dean; Beow Y Yeap; Patricia McManus; Andrew E Rosenberg; G Petur Nielsen; David C Harmon; Ira J Spiro; Kevin A Raskin; Herman D Suit; Sam S Yoon; Francis J Hornicek Journal: Int J Radiat Oncol Biol Phys Date: 2008-12-25 Impact factor: 7.038
Authors: Edwin Choy; Laura E MacConaill; Gregory M Cote; Long P Le; Jacson K Shen; Gunnlaugur P Nielsen; Anthony J Iafrate; Levi A Garraway; Francis J Hornicek; Zhenfeng Duan Journal: PLoS One Date: 2014-07-01 Impact factor: 3.240
Authors: Brenton Pennicooke; Ilya Laufer; Arjun Sahgal; Peter P Varga; Ziya L Gokaslan; Mark H Bilsky; Yoshiya J Yamada Journal: Spine (Phila Pa 1976) Date: 2016-10-15 Impact factor: 3.241