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Literature DB >> 15128580

Transformation of folate-consuming Lactobacillus gasseri into a folate producer.

Arno Wegkamp¹, Marjo Starrenburg, Willem M de Vos, Jeroen Hugenholtz, Wilbert Sybesma.

Abstract

Five genes essential for folate biosynthesis in Lactococcus lactis were cloned on a broad-host-range lactococcal vector and were transferred to the folate auxotroph Lactobacillus gasseri. As a result L. gasseri changed from a folate consumer to a folate producer. This principle can be used to increase folate levels in many fermented food products.

Entities: Chemical Species

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Year: 2004 PMID： 15128580 PMCID： PMC404390 DOI： 10.1128/AEM.70.5.3146-3148.2004

Source DB: PubMed Journal: Appl Environ Microbiol ISSN： 0099-2240 Impact factor: 4.792

12 in total

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Authors: Wilbert Sybesma; Marjo Starrenburg; Linda Tijsseling; Marcel H N Hoefnagel; Jeroen Hugenholtz
Journal: Appl Environ Microbiol Date: 2003-08 Impact factor: 4.792

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Journal: Appl Environ Microbiol Date: 2008-03-14 Impact factor: 4.792

Review 2. Genes and molecules of lactobacilli supporting probiotic action.

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Authors: Sander Sieuwerts; Frank A M de Bok; Jeroen Hugenholtz; Johan E T van Hylckama Vlieg
Journal: Appl Environ Microbiol Date: 2008-06-20 Impact factor: 4.792

Review 4. Biochemical Features of Beneficial Microbes: Foundations for Therapeutic Microbiology.

Authors: Melinda A Engevik; James Versalovic
Journal: Microbiol Spectr Date: 2017-10

5. Characterization of the role of para-aminobenzoic acid biosynthesis in folate production by Lactococcus lactis.

Authors: Arno Wegkamp; Wietske van Oorschot; Willem M de Vos; Eddy J Smid
Journal: Appl Environ Microbiol Date: 2007-02-16 Impact factor: 4.792

Review 6. 'Unknown' proteins and 'orphan' enzymes: the missing half of the engineering parts list--and how to find it.

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Journal: Biochem J Date: 2009-12-14 Impact factor: 3.857

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Authors: Geun Cheol Song; Hye Kyung Choi; Choong-Min Ryu
Journal: Ann Bot Date: 2013-03-07 Impact factor: 4.357