Literature DB >> 15124919

Development and application of Na+/Ca2+ exchange inhibitors.

Takahiro Iwamoto1, Satomi Kita.   

Abstract

The Na+/Ca2+ exchanger (NCX) is an ion transporter that exchanges Na+ and Ca2+ in either Ca2+ efflux or Ca2+ influx mode, depending on the ion gradients across the plasma membrane and the membrane potential. In heart, smooth muscle cells, neurons, and nephron cells, the NCX is thought to play an important role in the regulation of intracellular Ca2+ concentration. Recently, a novel selective inhibitor (KB-R7943 and SEA0400) of the Ca2+ influx mode of the NCX has been developed. NCX inhibitor is expected to be a pharmaceutical agent that offers effective protection against ischemia/reperfusion injury in several organs such as heart and kidney. Here, we summarize pharmacological profiles of KB-R7943 and SEA0400, the molecular mechanism of its action, and its future prospect as a novel pharmaceutical agent.

Entities:  

Mesh：

Substances：

Year:  2004        PMID： 15124919     DOI： 10.1023/b:mcbi.0000021367.42752.54

Source DB:  PubMed          Journal:  Mol Cell Biochem        ISSN： 0300-8177            Impact factor:   3.396


  33 in total

1.  Inhibition of Na+/Ca2+ exchange by KB-R7943: transport mode selectivity and antiarrhythmic consequences.

Authors:  C L Elias; A Lukas; S Shurraw; J Scott; A Omelchenko; G J Gross; M Hnatowich; L V Hryshko
Journal:  Am J Physiol Heart Circ Physiol       Date:  2001-09       Impact factor: 4.733

Review 2.  The Na+/Ca2+ exchange molecule: an overview.

Authors:  Kenneth D Philipson; Debora A Nicoll; Michela Ottolia; Beate D Quednau; Hannes Reuter; Scott John; Zhiyong Qiu
Journal:  Ann N Y Acad Sci       Date:  2002-11       Impact factor: 5.691

3.  Cellular regulation of sodium-calcium exchange.

Authors:  Madalina Condrescu; Kwabena Opuni; Basil M Hantash; John P Reeves
Journal:  Ann N Y Acad Sci       Date:  2002-11       Impact factor: 5.691

4.  [Effects of KB-R7943, a novel Na+/Ca2+ exchange inhibitor, on myocardial ischemia/reperfusion injury].

Authors:  A Nakamura; K Harada; H Sugimoto; F Nakajima; N Nishimura
Journal:  Nihon Yakurigaku Zasshi       Date:  1998-02

5.  The novel Na+/Ca2+ exchange inhibitor KB-R7943 protects CA1 neurons in rat hippocampal slices against hypoxic/hypoglycemic injury.

Authors:  U H Schröder; J Breder; C F Sabelhaus; K G Reymann
Journal:  Neuropharmacology       Date:  1999-02       Impact factor: 5.250

6.  Structural domains influencing sensitivity to isothiourea derivative inhibitor KB-R7943 in cardiac Nna(+)/Ca(2+) exchanger.

Authors:  T Iwamoto; S Kita; A Uehara; Y Inoue; Y Taniguchi; I Imanaga; M Shigekawa
Journal:  Mol Pharmacol       Date:  2001-03       Impact factor: 4.436

7.  Attenuation of ischemia/reperfusion-induced renal injury in mice deficient in Na+/Ca2+ exchanger.

Authors:  Junji Yamashita; Satomi Kita; Takahiro Iwamoto; Masaya Ogata; Masanori Takaoka; Naoko Tazawa; Mitsunori Nishikawa; Koji Wakimoto; Munekazu Shigekawa; Issei Komuro; Yasuo Matsumura
Journal:  J Pharmacol Exp Ther       Date:  2003-01       Impact factor: 4.030

8.  Cloning of the NCX2 isoform of the plasma membrane Na(+)-Ca2+ exchanger.

Authors:  Z Li; S Matsuoka; L V Hryshko; D A Nicoll; M M Bersohn; E P Burke; R P Lifton; K D Philipson
Journal:  J Biol Chem       Date:  1994-07-01       Impact factor: 5.157

9.  Cloning of a third mammalian Na+-Ca2+ exchanger, NCX3.

Authors:  D A Nicoll; B D Quednau; Z Qui; Y R Xia; A J Lusis; K D Philipson
Journal:  J Biol Chem       Date:  1996-10-04       Impact factor: 5.157

10.  A novel isothiourea derivative selectively inhibits the reverse mode of Na+/Ca2+ exchange in cells expressing NCX1.

Authors:  T Iwamoto; T Watano; M Shigekawa
Journal:  J Biol Chem       Date:  1996-09-13       Impact factor: 5.157
View more
  8 in total

1.  External bioenergy-induced increases in intracellular free calcium concentrations are mediated by Na+/Ca2+ exchanger and L-type calcium channel.

Authors:  Juliann G Kiang; John A Ives; Wayne B Jonas
Journal:  Mol Cell Biochem       Date:  2005-03       Impact factor: 3.396

Review 2.  Taming the neutrophil: calcium clearance and influx mechanisms as novel targets for pharmacological control.

Authors:  G Tintinger; H C Steel; R Anderson
Journal:  Clin Exp Immunol       Date:  2005-08       Impact factor: 4.330

Review 3.  Ca2+ regulation of ion transport in the Na+/Ca2+ exchanger.

Authors:  Mark Hilge
Journal:  J Biol Chem       Date:  2012-07-20       Impact factor: 5.157

4.  Contribution of the Na+/Ca2+ exchanger to rapid Ca2+ release in cardiomyocytes.

Authors:  Glenn T Lines; Jørn B Sande; William E Louch; Halvor K Mørk; Per Grøttum; Ole M Sejersted
Journal:  Biophys J       Date:  2006-05-05       Impact factor: 4.033

5.  The plasma membrane Na+/Ca2+ exchange inhibitor KB-R7943 is also a potent inhibitor of the mitochondrial Ca2+ uniporter.

Authors:  J Santo-Domingo; L Vay; E Hernández-Sanmiguel; C D Lobatón; A Moreno; M Montero; J Alvarez
Journal:  Br J Pharmacol       Date:  2007-04-30       Impact factor: 8.739

6.  Na(+)/Ca(2+) exchanger inhibition exerts a positive inotropic effect in the rat heart, but fails to influence the contractility of the rabbit heart.

Authors:  A S Farkas; K Acsai; N Nagy; A Tóth; F Fülöp; G Seprényi; P Birinyi; P P Nánási; T Forster; M Csanády; J G Papp; A Varró; A Farkas
Journal:  Br J Pharmacol       Date:  2008-03-10       Impact factor: 8.739

7.  Sodium-calcium exchange in intracellular calcium handling of human airway smooth muscle.

Authors:  Venkatachalem Sathish; Philippe F Delmotte; Michael A Thompson; Christina M Pabelick; Gary C Sieck; Y S Prakash
Journal:  PLoS One       Date:  2011-08-15       Impact factor: 3.240

8.  Differential contributions of Ca2+ -activated K+ channels and Na+ /K+ -ATPases to the generation of the slow afterhyperpolarization in CA1 pyramidal cells.

Authors:  Manindra Nath Tiwari; Sandesh Mohan; Yoav Biala; Yoel Yaari
Journal:  Hippocampus       Date:  2018-02-27       Impact factor: 3.899
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.