Literature DB >> 10218875

The novel Na+/Ca2+ exchange inhibitor KB-R7943 protects CA1 neurons in rat hippocampal slices against hypoxic/hypoglycemic injury.

U H Schröder1, J Breder, C F Sabelhaus, K G Reymann.   

Abstract

The selective Na+/Ca2+ exchange inhibitor 2-[2-[4-(4-nitrobenzyloxy)phenyl]ethyl]isothiourea methanesulfonate (KB-R7943), significantly improves recovery of population spike amplitudes in rat hippocampal slices after hypoxia/hypoglycemia. Our data suggest that the Na+/Ca2+ exchanger, operating in reverse mode, contributes to hypoxia/hypoglycemia-induced injury in CA1 neurons.

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Year:  1999        PMID： 10218875     DOI： 10.1016/s0028-3908(98)00198-1

Source DB:  PubMed          Journal:  Neuropharmacology        ISSN： 0028-3908            Impact factor:   5.250


  18 in total

Review 1.  Development and application of Na+/Ca2+ exchange inhibitors.

Authors:  Takahiro Iwamoto; Satomi Kita
Journal:  Mol Cell Biochem       Date:  2004-04       Impact factor: 3.396

2.  Disruption of ionic and cell volume homeostasis in cerebral ischemia: The perfect storm.

Authors:  Alexander A Mongin
Journal:  Pathophysiology       Date:  2007-10-25

3.  Differential hippocampal protection when blocking intracellular sodium and calcium entry during traumatic brain injury in rats.

Authors:  Xueren Zhao; Fredric A Gorin; Robert F Berman; Bruce G Lyeth
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4.  Neuroprotective effect of KB-R7943 against glutamate excitotoxicity is related to mild mitochondrial depolarization.

Authors:  T P Storozhevykh; Ya E Senilova; T Brustovetsky; V G Pinelis; N Brustovetsky
Journal:  Neurochem Res       Date:  2009-09-22       Impact factor: 3.996

5.  Mechanical strain injury increases intracellular sodium and reverses Na+/Ca2+ exchange in cortical astrocytes.

Authors:  Candace L Floyd; Fredric A Gorin; Bruce G Lyeth
Journal:  Glia       Date:  2005-07       Impact factor: 7.452

6.  Amiloride Analogs as ASIC1a Inhibitors.

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7.  Calpains and delayed calcium deregulation in excitotoxicity.

Authors:  Inês M Araújo; Bruno P Carreira; Caetana M Carvalho; Arsélio P Carvalho
Journal:  Neurochem Res       Date:  2010-11-26       Impact factor: 3.996

Review 8.  Does Na⁺/Ca²⁺ exchanger, NCX, represent a new druggable target in stroke intervention?

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Journal:  Transl Stroke Res       Date:  2013-11-19       Impact factor: 6.829

9.  Excitatory mechanisms in the suprachiasmatic nucleus: the role of AMPA/KA glutamate receptors.

Authors:  Stephan Michel; Jason Itri; Christopher S Colwell
Journal:  J Neurophysiol       Date:  2002-08       Impact factor: 2.714

10.  Modes of Neuronal Calcium Entry and Homeostasis following Cerebral Ischemia.

Authors:  J L Cross; B P Meloni; A J Bakker; S Lee; N W Knuckey
Journal:  Stroke Res Treat       Date:  2010-11-01
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