| Literature DB >> 15120958 |
T A Niewold1, M Meinen, J van der Meulen.
Abstract
Intestinal fatty acid binding protein (I-FABP) is an intracellular epithelial protein in the intestinal mucosa of many animals. I-FABP appears in the circulation following epithelial damage, and in humans, is proven to be a parameter for damage to the mucosa. In this paper, an ELISA test designed for human I-FABP analysis was used to assay pig blood samples. The test recognized I-FABP cloned from pig small intestine and expressed in Escherichia coli. Furthermore, in our experimental model of (low flow) intestinal ischemia and reperfusion a significant rise in plasma I-FABP concentrations 15-30 min after clamping of the mesenteric artery was demonstrated. This is the first report that in pigs circulating I-FABP is a useful marker for (mild) intestinal injury, and could possibly be used to monitor (intestinal) health in clinical practice.Entities:
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Year: 2004 PMID： 15120958 DOI： 10.1016/j.rvsc.2004.02.006
Source DB: PubMed Journal: Res Vet Sci ISSN： 0034-5288 Impact factor: 2.534