Literature DB >> 17589917

Biomarkers for radiation-induced small bowel epithelial damage: an emerging role for plasma Citrulline.

Ludy Lutgens1, Philippe Lambin.   

Abstract

Reduction of cancer treatment-induced mucosal injury has been recognized as an important target for improving the therapeutic ratio as well as reducing the economic burden associated with these treatment related sequellae. Clinical studies addressing this issue are hampered by the fact that specific objective parameters, which enable monitoring of damage in routine clinical practice, are lacking. This review summarizes pros and cons of currently available endpoints for intestinal injury. The metabolic background and characteristics of plasma citrulline, a recently investigated biomarker specifically for small intestinal injury, are discussed in more detail.

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Year:  2007        PMID： 17589917      PMCID： PMC4172608          DOI： 10.3748/wjg.v13.i22.3033

Source DB:  PubMed          Journal:  World J Gastroenterol        ISSN： 1007-9327            Impact factor:   5.742


  146 in total

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Authors:  H G Windmueller; A E Spaeth
Journal:  Arch Biochem Biophys       Date:  1975-12       Impact factor: 4.013

2.  Synthesis of citrulline and arginine from proline in enterocytes of postnatal pigs.

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Journal:  Am J Physiol       Date:  1997-06

Review 3.  Intestinal permeability: an overview.

Authors:  I Bjarnason; A MacPherson; D Hollander
Journal:  Gastroenterology       Date:  1995-05       Impact factor: 22.682

4.  An association of lower serum citrulline levels within 30 days of acute rejection in patients following small intestine transplantation.

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Journal:  Transplant Proc       Date:  2006 Jul-Aug       Impact factor: 1.066

5.  Chemoradiation as primary or adjuvant treatment for locally advanced carcinoma of the vulva.

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Journal:  Int J Radiat Oncol Biol Phys       Date:  2000-07-15       Impact factor: 7.038

6.  Influence of glutamine-supplemented parenteral nutrition on intestinal amino acid metabolism in rats after small bowel resection.

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Journal:  Surg Today       Date:  1996       Impact factor: 2.549

7.  Inhibition of intestinal citrulline synthesis causes severe growth retardation in rats.

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Journal:  Am J Physiol       Date:  1985-12

8.  Plasma urea-cycle-related amino acids, ammonium levels, and urinary orotic acid excretion in short-bowel patients managed with an oral diet.

Authors:  A M Pita; Y Wakabayashi; M A Fernandez-Bustos; N Virgili; E Riudor; J Soler; M Farriol
Journal:  Clin Nutr       Date:  2003-02       Impact factor: 7.324

9.  Glutamine-enriched enteral diet increases renal arginine production.

Authors:  A P Houdijk; P A van Leeuwen; T Teerlink; E L Flinkerbusch; M A Boermeester; H P Sauerwein; R I Wesdorp
Journal:  JPEN J Parenter Enteral Nutr       Date:  1994 Sep-Oct       Impact factor: 4.016

10.  Defining normal plasma citrulline in intestinal transplant recipients.

Authors:  Gabriel E Gondolesi; Stuart S Kaufman; Claude Sansaricq; Margret S Magid; Kimiyo Raymond; Liesl P Iledan; Ye Tao; Sander S Florman; Neal S LeLeiko; Thomas M Fishbein
Journal:  Am J Transplant       Date:  2004-03       Impact factor: 8.086
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  36 in total

1.  Citrulline as a Biomarker in the Murine Total-Body Irradiation Model: Correlation of Circulating and Tissue Citrulline to Small Intestine Epithelial Histopathology.

Authors:  Jace W Jones; Gregory Tudor; Fei Li; Yan Tong; Barry Katz; Ann M Farese; Thomas J MacVittie; Catherine Booth; Maureen A Kane
Journal:  Health Phys       Date:  2015-11       Impact factor: 1.316

2.  Tissue toxicity induced by ionizing radiation to the normal intestine: understanding the pathophysiological mechanisms to improve the medical management.

Authors:  M-C Vozenin-Brotons
Journal:  World J Gastroenterol       Date:  2007-06-14       Impact factor: 5.742

3.  Plasma citrulline as a biomarker for enterocyte integrity in pediatric blood and BMT.

Authors:  J B Karlik; A Kesavan; M L Nieder; R Hawks; Z Jin; M Bhatia; E J Ladas
Journal:  Bone Marrow Transplant       Date:  2013-11-04       Impact factor: 5.483

4.  Citrulline as a Biomarker for Gastrointestinal-Acute Radiation Syndrome: Species Differences and Experimental Condition Effects.

Authors:  K Bujold; M Hauer-Jensen; O Donini; A Rumage; D Hartman; H P Hendrickson; J Stamatopoulos; H Naraghi; M Pouliot; A Ascah; M Sebastian; M K Pugsley; K Wong; S Authier
Journal:  Radiat Res       Date:  2016-06-28       Impact factor: 2.841

5.  Plasma citrulline as surrogate marker of intestinal inflammation in pediatric and adolescent with Crohn's disease: preliminary report.

Authors:  Antonella Diamanti; Daniela Knafelz; Fabio Panetta; Fiammetta Bracci; Manuela Gambarara; Bronislava Papadatou; Antonella Daniele; Bianca M Goffredo; Simona Pezzi; Giuliano Torre
Journal:  Int J Colorectal Dis       Date:  2011-06-14       Impact factor: 2.571

6.  Surface-enhanced Raman spectroscopy competitive binding biosensor development utilizing surface modification of silver nanocubes and a citrulline aptamer.

Authors:  Brian M Walton; George W Jackson; Nicolaas Deutz; Gerard Cote
Journal:  J Biomed Opt       Date:  2017-07-01       Impact factor: 3.170

Review 7.  Radiation enteritis.

Authors:  Ali H Harb; Carla Abou Fadel; Ala I Sharara
Journal:  Curr Gastroenterol Rep       Date:  2014

8.  Significance of bioindicators to predict survival in irradiated minipigs.

Authors:  Maria Moroni; Matthias Port; Amory Koch; Jatinder Gulani; Viktor Meineke; Michael Abend
Journal:  Health Phys       Date:  2014-06       Impact factor: 1.316

9.  Oral interleukin 11 as a countermeasure to lethal total-body irradiation in a murine model.

Authors:  Alexander F Burnett; Prabath G Biju; Huanli Lui; Martin Hauer-Jensen
Journal:  Radiat Res       Date:  2013-11-12       Impact factor: 2.841

10.  Total Body Irradiation in the "Hematopoietic" Dose Range Induces Substantial Intestinal Injury in Non-Human Primates.

Authors:  Junru Wang; Lijian Shao; Howard P Hendrickson; Liya Liu; Jianhui Chang; Yi Luo; John Seng; Mylene Pouliot; Simon Authier; Daohong Zhou; William Allaben; Martin Hauer-Jensen
Journal:  Radiat Res       Date:  2015-10-23       Impact factor: 2.841
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