Literature DB >> 15110843

Synthesis and activity of 1H-benzimidazole and 1H-benzotriazole derivatives as inhibitors of Acanthamoeba castellanii.

Katarzyna Kopańska1, Andzelika Najda, Justyna Zebrowska, Lidia Chomicz, Janusz Piekarczyk, Przemysław Myjak, Maria Bretner.   

Abstract

Chloro-, bromo- and methyl- analogues of 1H-benzimidazole and 1H-benzotriazole and their N-alkyl derivatives have been synthesized and tested in vitro against the protozoa Acanthamoeba castellanii. The results indicate that 5,6-dimethyl-1H-benzotriazole (11) and 5,6-dibromo-1H-benzotriazole (14) have higher efficacy than the antiprotozoal agent chlorohexidine.

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Year:  2004        PMID： 15110843     DOI： 10.1016/j.bmc.2004.03.022

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  20 in total

1.  Mild and General Access to Diverse 1H-Benzotriazoles via Diboron-Mediated N-OH Deoxygenation and Palladium-Catalyzed C-C and C-N Bond Formation.

Authors:  Venkateshwarlu Gurram; Hari K Akula; Ramesh Garlapati; Narender Pottabathini; Mahesh K Lakshman
Journal:  Adv Synth Catal       Date:  2015-02-09       Impact factor: 5.837

2.  The Disappearing Director: The Case of Directed N-Arylation via a Removable Hydroxyl Group.

Authors:  Magdalena R Andrzejewska; Prasanna K Vuram; Narender Pottabathini; Venkateshwarlu Gurram; Siva Subrahmanyam Relangi; Kirill A Korvinson; Raju Doddipalla; Lothar Stahl; Michelle C Neary; Padmanava Pradhan; Somesh Sharma; Mahesh K Lakshman
Journal:  Adv Synth Catal       Date:  2018-04-16       Impact factor: 5.837

3.  Imidazolium 4-amino-benzoate.

Authors:  Rodolfo Moreno-Fuquen; Alan R Kennedy; Denise Gilmour; R H De Almeida Santos; Rommel B Viana
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-11-11

4.  4-[(1H-Benzotriazol-1-yl)meth-yl]benzo-nitrile.

Authors:  Wen-Xiang Wang; Hong Zhao
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2008-05-03

5.  2-(1H-Benzotriazol-1-yl)-1-phenyl-ethanol.

Authors:  Ozden Ozel Güven; Meral Bayraktar; Simon J Coles; Tuncer Hökelek
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-03-27

6.  1-[2-(4-Chloro-benz-yloxy)-2-phenyl-ethyl]-1H-benzotriazole.

Authors:  Ozden Ozel Güven; Meral Bayraktar; Simon J Coles; Tuncer Hökelek
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-05-08

7.  Benzyne click chemistry: synthesis of benzotriazoles from benzynes and azides.

Authors:  Feng Shi; Jesse P Waldo; Yu Chen; Richard C Larock
Journal:  Org Lett       Date:  2008-05-14       Impact factor: 6.005

8.  Reinvestigation of the synthesis and evaluation of [N-methyl-(11)C]vorozole, a radiotracer targeting cytochrome P450 aromatase.

Authors:  Sung Won Kim; Anat Biegon; Zachary E Katsamanis; Carolin W Ehrlich; Jacob M Hooker; Colleen Shea; Lisa Muench; Youwen Xu; Payton King; Pauline Carter; David L Alexoff; Joanna S Fowler
Journal:  Nucl Med Biol       Date:  2009-04       Impact factor: 2.408

9.  Synthesis, Crystal Structure, and DNA-Binding Studies of a Nickel(II) Complex with the Bis(2-benzimidazolymethyl)amine Ligand.

Authors:  Huilu Wu; Tao Sun; Ke Li; Bin Liu; Fan Kou; Fei Jia; Jingkun Yuan; Ying Bai
Journal:  Bioinorg Chem Appl       Date:  2011-06-30       Impact factor: 7.778

10.  A new polymorph of 2-(2H-benzotriazol-2-yl)acetic acid.

Authors:  Guloy Alieva; Jamshid Ashurov; Nasir Mukhamedov; Nusrat Parpiev
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-09-01
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