Literature DB >> 1510445

Analysis of peptidoglycan precursors in vancomycin-resistant enterococci.

D Billot-Klein1, L Gutmann, E Collatz, J van Heijenoort.   

Abstract

Analysis by high-pressure liquid chromatography of the cytoplasmic peptidoglycan precursors of a high- and a low-level vancomycin-resistant Enterococcus spp. was performed before and after induction of resistance. This analysis showed a decrease of the D-Ala-D-Ala and UDP-MurNac-pentapeptide pools, an increase of the UDP-MurNac-tripeptide pool, and the appearance of new UDP-MurNac-containing material. These results lead us to suggest that the vancomycin-induced carboxypeptidase activity cleaves the D-Ala-D-Ala (L. Gutmann, D. Billot-Klein, S. Al-Obeid, I. Klare, S. Francoul, E. Collatz, and J. van Heijenoort, Antimicrob. Agents Chemother. 36:77-80, 1992), which in turn would prevent formation of the normal UDP-MurNac-pentapeptide and thereby of the vancomycin target. The novel UDP-MurNac-containing material is thought to correspond to peptidoglycan precursors which might be synthesized by an alternate pathway (T. D. H. Bugg, G. D. Wright, S. Dutka-Malen, M. Arthur, P. Courvalin, and C. T. Walsh, Biochemistry 30:10408-10415, 1991) and which would be unable to bind vancomycin in glycopeptide-resistant enterococci.

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Year:  1992        PMID： 1510445      PMCID： PMC191609          DOI： 10.1128/AAC.36.7.1487

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  18 in total

1.  The VANA glycopeptide resistance protein is related to D-alanyl-D-alanine ligase cell wall biosynthesis enzymes.

Authors:  S Dutka-Malen; C Molinas; M Arthur; P Courvalin
Journal:  Mol Gen Genet       Date:  1990-12

Review 2.  Resistance of enterococci to glycopeptides.

Authors:  P Courvalin
Journal:  Antimicrob Agents Chemother       Date:  1990-12       Impact factor: 5.191

3.  Comparison of vancomycin-inducible proteins from four strains of Enterococci.

Authors:  S al-Obeid; L Gutmann; D M Shlaes; R Williamson; E Collatz
Journal:  FEMS Microbiol Lett       Date:  1990-06-15       Impact factor: 2.742

4.  Release of D-alanyl-D-alanine from the precursor of the cell wall peptidoglycan by a peptidase of Escherichia coli K 12.

Authors:  B Gondré; B Flouret; J van Heijenoort
Journal:  Biochimie       Date:  1973       Impact factor: 4.079

5.  Purification and characterization of the D-alanyl-D-alanine-adding enzyme from Escherichia coli.

Authors:  K Duncan; J van Heijenoort; C T Walsh
Journal:  Biochemistry       Date:  1990-03-06       Impact factor: 3.162

Review 6.  Resistance to vancomycin and teicoplanin: an emerging clinical problem.

Authors:  A P Johnson; A H Uttley; N Woodford; R C George
Journal:  Clin Microbiol Rev       Date:  1990-07       Impact factor: 26.132

7.  Inducible resistance to vancomycin in Enterococcus faecium D366.

Authors:  R Williamson; S Al-Obeid; J H Shlaes; F W Goldstein; D M Shlaes
Journal:  J Infect Dis       Date:  1989-06       Impact factor: 5.226

8.  Complete analysis of cellular nucleotides by two-dimensional thin layer chromatography.

Authors:  B R Bochner; B N Ames
Journal:  J Biol Chem       Date:  1982-08-25       Impact factor: 5.157

9.  Inducible carboxypeptidase activity in vancomycin-resistant enterococci.

Authors:  L Gutmann; D Billot-Klein; S al-Obeid; I Klare; S Francoual; E Collatz; J van Heijenoort
Journal:  Antimicrob Agents Chemother       Date:  1992-01       Impact factor: 5.191

10.  Identification of vancomycin resistance protein VanA as a D-alanine:D-alanine ligase of altered substrate specificity.

Authors:  T D Bugg; S Dutka-Malen; M Arthur; P Courvalin; C T Walsh
Journal:  Biochemistry       Date:  1991-02-26       Impact factor: 3.162
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  19 in total

1.  Peptidoglycan structure of Lactobacillus casei, a species highly resistant to glycopeptide antibiotics.

Authors:  D Billot-Klein; R Legrand; B Schoot; J van Heijenoort; L Gutmann
Journal:  J Bacteriol       Date:  1997-10       Impact factor: 3.490

Review 2.  Current perspectives on glycopeptide resistance.

Authors:  N Woodford; A P Johnson; D Morrison; D C Speller
Journal:  Clin Microbiol Rev       Date:  1995-10       Impact factor: 26.132

3.  Hidden Mode of Action of Glycopeptide Antibiotics: Inhibition of Wall Teichoic Acid Biosynthesis.

Authors:  Manmilan Singh; James Chang; Lauryn Coffman; Sung Joon Kim
Journal:  J Phys Chem B       Date:  2017-04-14       Impact factor: 2.991

Review 4.  Genetics and mechanisms of glycopeptide resistance in enterococci.

Authors:  M Arthur; P Courvalin
Journal:  Antimicrob Agents Chemother       Date:  1993-08       Impact factor: 5.191

5.  Association constants for the binding of vancomycin and teicoplanin to N-acetyl-D-alanyl-D-alanine and N-acetyl-D-alanyl-D-serine.

Authors:  D Billot-Klein; D Blanot; L Gutmann; J van Heijenoort
Journal:  Biochem J       Date:  1994-12-15       Impact factor: 3.857

6.  vanM, a new glycopeptide resistance gene cluster found in Enterococcus faecium.

Authors:  Xiaogang Xu; Dongfang Lin; Guoquan Yan; Xinyu Ye; Shi Wu; Yan Guo; Demei Zhu; Fupin Hu; Yingyuan Zhang; Fu Wang; George A Jacoby; Minggui Wang
Journal:  Antimicrob Agents Chemother       Date:  2010-08-23       Impact factor: 5.191

7.  Penicillin tolerance and modification of lipoteichoic acid associated with expression of vancomycin resistance in VanB-type Enterococcus faecium D366.

Authors:  L Gutmann; S Al-Obeid; D Billot-Klein; E Ebnet; W Fischer
Journal:  Antimicrob Agents Chemother       Date:  1996-01       Impact factor: 5.191

8.  Synergy and resistance to synergy between beta-lactam antibiotics and glycopeptides against glycopeptide-resistant strains of Enterococcus faecium.

Authors:  L Gutmann; S al-Obeid; D Billot-Klein; M L Guerrier; E Collatz
Journal:  Antimicrob Agents Chemother       Date:  1994-04       Impact factor: 5.191

9.  Alterations in peptidoglycan precursors and vancomycin susceptibility in Tn917 insertion mutants of Enterococcus faecalis 221.

Authors:  S Handwerger
Journal:  Antimicrob Agents Chemother       Date:  1994-03       Impact factor: 5.191

10.  Modification of peptidoglycan precursors is a common feature of the low-level vancomycin-resistant VANB-type Enterococcus D366 and of the naturally glycopeptide-resistant species Lactobacillus casei, Pediococcus pentosaceus, Leuconostoc mesenteroides, and Enterococcus gallinarum.

Authors:  D Billot-Klein; L Gutmann; S Sablé; E Guittet; J van Heijenoort
Journal:  J Bacteriol       Date:  1994-04       Impact factor: 3.490
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