Literature DB >> 1534213

Inducible carboxypeptidase activity in vancomycin-resistant enterococci.

L Gutmann1, D Billot-Klein, S al-Obeid, I Klare, S Francoual, E Collatz, J van Heijenoort.   

Abstract

Vancomycin was found to coinduce DD-carboxypeptidase activity, together with resistance, in eight low- or high-level glycopeptide-resistant strains of enterococci. The constitutively resistant mutant (MT10) of a low-level-resistant strain of Enterococcus faecium (D366) spontaneously expressed a level of carboxypeptidase similar to that of the induced strain D366. Pentapeptide, UDP-MurNac-pentapeptide, as well as D-alanyl-D-alanine were in vitro substrates for the carboxypeptidase which was not inhibited by penicillin. The level of vancomycin resistance correlated roughly with the level of carboxypeptidase activity. We infer from these results that the carboxypeptidase is one component of the glycopeptide resistance mechanism.

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Year:  1992        PMID： 1534213      PMCID： PMC189230          DOI： 10.1128/AAC.36.1.77

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  20 in total

Review 1.  Resistance of enterococci to glycopeptides.

Authors:  P Courvalin
Journal:  Antimicrob Agents Chemother       Date:  1990-12       Impact factor: 5.191

2.  Protein measurement with the Folin phenol reagent.

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Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

3.  Plasmid-mediated resistance to vancomycin and teicoplanin in Enterococcus faecium.

Authors:  R Leclercq; E Derlot; J Duval; P Courvalin
Journal:  N Engl J Med       Date:  1988-07-21       Impact factor: 91.245

4.  Reverse-phase high-pressure liquid chromatography of uridine diphosphate N-acetylmuramyl peptide precursors of bacterial cell wall peptidoglycan.

Authors:  B Flouret; D Mengin-Lecreulx; J van Heijenoort
Journal:  Anal Biochem       Date:  1981-06       Impact factor: 3.365

5.  Solubilization and isolation of the membrane-bound DD-carboxypeptidase of Streptococcus faecalis ATCC9790. Properties of the purified enzyme.

Authors:  J Coyette; J M Ghuysen; R Fontana
Journal:  Eur J Biochem       Date:  1978-07-17

6.  Kinetic evidence for the formation of D-alanyl phosphate in the mechanism of D-alanyl-D-alanine ligase.

Authors:  L S Mullins; L E Zawadzke; C T Walsh; F M Raushel
Journal:  J Biol Chem       Date:  1990-06-05       Impact factor: 5.157

7.  In vitro susceptibility studies of vancomycin-resistant Enterococcus faecalis.

Authors:  D F Sahm; J Kissinger; M S Gilmore; P R Murray; R Mulder; J Solliday; B Clarke
Journal:  Antimicrob Agents Chemother       Date:  1989-09       Impact factor: 5.191

8.  Inducible, transferable resistance to vancomycin in Enterococcus faecalis A256.

Authors:  D M Shlaes; A Bouvet; C Devine; J H Shlaes; S al-Obeid; R Williamson
Journal:  Antimicrob Agents Chemother       Date:  1989-02       Impact factor: 5.191

9.  Characterization of vancomycin resistance in Enterococcus faecium and Enterococcus faecalis.

Authors:  T I Nicas; C Y Wu; J N Hobbs; D A Preston; N E Allen
Journal:  Antimicrob Agents Chemother       Date:  1989-07       Impact factor: 5.191

10.  Identification of vancomycin resistance protein VanA as a D-alanine:D-alanine ligase of altered substrate specificity.

Authors:  T D Bugg; S Dutka-Malen; M Arthur; P Courvalin; C T Walsh
Journal:  Biochemistry       Date:  1991-02-26       Impact factor: 3.162
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  32 in total

1.  Molecular cloning, sequence analysis, and characterization of a penicillin-resistant DD-carboxypeptidase of Myxococcus xanthus.

Authors:  Y Kimura; Y Takashima; Y Tokumasu; M Sato
Journal:  J Bacteriol       Date:  1999-08       Impact factor: 3.490

2.  Molecular epidemiology and antibiotic susceptibility of enterococci in Cincinnati, Ohio: a prospective citywide survey.

Authors:  D E Perlada; A G Smulian; M T Cushion
Journal:  J Clin Microbiol       Date:  1997-09       Impact factor: 5.948

3.  Peptidoglycan structure of Lactobacillus casei, a species highly resistant to glycopeptide antibiotics.

Authors:  D Billot-Klein; R Legrand; B Schoot; J van Heijenoort; L Gutmann
Journal:  J Bacteriol       Date:  1997-10       Impact factor: 3.490

Review 4.  Current perspectives on glycopeptide resistance.

Authors:  N Woodford; A P Johnson; D Morrison; D C Speller
Journal:  Clin Microbiol Rev       Date:  1995-10       Impact factor: 26.132

5.  VanD-type glycopeptide-resistant Enterococcus faecium BM4339.

Authors:  B Perichon; P Reynolds; P Courvalin
Journal:  Antimicrob Agents Chemother       Date:  1997-09       Impact factor: 5.191

6.  Peptidoglycan Compositional Analysis of Enterococcus faecalis Biofilm by Stable Isotope Labeling by Amino Acids in a Bacterial Culture.

Authors:  James D Chang; Ashley G Wallace; Erin E Foster; Sung Joon Kim
Journal:  Biochemistry       Date:  2018-02-02       Impact factor: 3.162

7.  Analysis of peptidoglycan precursors in vancomycin-resistant Enterococcus gallinarum BM4174.

Authors:  P E Reynolds; H A Snaith; A J Maguire; S Dutka-Malen; P Courvalin
Journal:  Biochem J       Date:  1994-07-01       Impact factor: 3.857

8.  Altered peptidoglycan composition in vancomycin-resistant Enterococcus faecalis.

Authors:  B L de Jonge; S Handwerger; D Gage
Journal:  Antimicrob Agents Chemother       Date:  1996-04       Impact factor: 5.191

9.  Alterations in peptidoglycan precursors and vancomycin susceptibility in Tn917 insertion mutants of Enterococcus faecalis 221.

Authors:  S Handwerger
Journal:  Antimicrob Agents Chemother       Date:  1994-03       Impact factor: 5.191

10.  Vancomycin and oritavancin have different modes of action in Enterococcus faecium.

Authors:  Gary J Patti; Sung Joon Kim; Tsyr-Yan Yu; Evelyne Dietrich; Kelly S E Tanaka; Thomas R Parr; Adel Rafai Far; Jacob Schaefer
Journal:  J Mol Biol       Date:  2009-07-01       Impact factor: 5.469
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