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Literature DB >> 1510408

Ofloxacin versus doxycycline for treatment of cervical infection with Chlamydia trachomatis.

T M Hooton¹, B E Batteiger, F N Judson, S L Spruance, W E Stamm.

Abstract

Women with culture-proven Chlamydia trachomatis cervical infection were randomized to receive either ofloxacin (300 mg) or doxycycline (100 mg), orally twice daily for 7 days. All 56 had negative cultures 5 to 9 days after treatment. Four weeks after treatment, 26 (93%) of 28 ofloxacin-treated patients and all 22 doxycycline-treated patients were cured. We conclude that 300 mg of ofloxacin given twice daily for 7 days provides effective therapy for chlamydial infection of the cervix.

Entities: Chemical Disease Species

Mesh：

Substances：
Ofloxacin
Doxycycline

Year: 1992 PMID： 1510408 PMCID： PMC188853 DOI： 10.1128/AAC.36.5.1144

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

8 in total

Review 1. Treatment of genitourinary tract infections with fluoroquinolones: clinical efficacy in genital infections and adverse effects.

Authors: D C Hooper; J S Wolfson
Journal: Antimicrob Agents Chemother Date: 1989-10 Impact factor: 5.191

Review 2. Treatment of genitourinary tract infections with fluoroquinolones: activity in vitro, pharmacokinetics, and clinical efficacy in urinary tract infections and prostatitis.

Authors: J S Wolfson; D C Hooper
Journal: Antimicrob Agents Chemother Date: 1989-10 Impact factor: 5.191

3. Ciprofloxacin compared with doxycycline for nongonococcal urethritis. Ineffectiveness against Chlamydia trachomatis due to relapsing infection.

Authors: T M Hooton; M E Rogers; T G Medina; L E Kuwamura; C Ewers; P L Roberts; W E Stamm
Journal: JAMA Date: 1990-09-19 Impact factor: 56.272

4. Mucopurulent cervicitis--the ignored counterpart in women of urethritis in men.

Authors: R C Brunham; J Paavonen; C E Stevens; N Kiviat; C C Kuo; C W Critchlow; K K Holmes
Journal: N Engl J Med Date: 1984-07-05 Impact factor: 91.245

5. Efficacy of ofloxacin in the treatment of non-gonococcal urethritis in men and genital infections caused by Chlamydia trachomatis in men and women.

Authors: A T Nayagam; G L Ridgway; J D Oriel
Journal: J Antimicrob Chemother Date: 1988-09 Impact factor: 5.790

6. Comparison of ofloxacin with doxycycline in the treatment of non-gonococcal urethritis and cervical chlamydial infection.

Authors: V S Kitchen; C Donegan; H Ward; B Thomas; J R Harris; D Taylor-Robinson
Journal: J Antimicrob Chemother Date: 1990-11 Impact factor: 5.790

7. Evaluation of ofloxacin in the treatment of mucopurulent cervicitis: response of chlamydia-positive and chlamydia-negative forms.

Authors: V Chandeying; S Sutthijumroon; S Tungphaisal
Journal: J Med Assoc Thai Date: 1989-06

8. Randomized comparison of ofloxacin and doxycycline for chlamydia and ureaplasma urethritis and cervicitis.

Authors: W J Mogabgab; B Holmes; M Murray; R Beville; F B Lutz; K J Tack
Journal: Chemotherapy Date: 1990 Impact factor: 2.544

8 in total

12 in total

9. Periodic health examination, 1996 update: 2. Screening for chlamydial infections. Canadian Task Force on the Periodic Health Examination.

Authors: H D Davies; E E Wang
Journal: CMAJ Date: 1996-06-01 Impact factor: 8.262

Review 10. Quinolones in sexually transmitted diseases. Global experience.

Authors: G L Ridgway
Journal: Drugs Date: 1995 Impact factor: 9.546

Ofloxacin versus doxycycline for treatment of cervical infection with Chlamydia trachomatis.

Review 1. Treatment of genitourinary tract infections with fluoroquinolones: clinical efficacy in genital infections and adverse effects.

Review 2. Treatment of genitourinary tract infections with fluoroquinolones: activity in vitro, pharmacokinetics, and clinical efficacy in urinary tract infections and prostatitis.

3. Ciprofloxacin compared with doxycycline for nongonococcal urethritis. Ineffectiveness against Chlamydia trachomatis due to relapsing infection.

4. Mucopurulent cervicitis--the ignored counterpart in women of urethritis in men.

5. Efficacy of ofloxacin in the treatment of non-gonococcal urethritis in men and genital infections caused by Chlamydia trachomatis in men and women.

6. Comparison of ofloxacin with doxycycline in the treatment of non-gonococcal urethritis and cervical chlamydial infection.

7. Evaluation of ofloxacin in the treatment of mucopurulent cervicitis: response of chlamydia-positive and chlamydia-negative forms.

8. Randomized comparison of ofloxacin and doxycycline for chlamydia and ureaplasma urethritis and cervicitis.

1. Control of genital chlamydial infection.

Review 2. Concurrent gonococcal and chlamydial infection: how best to treat.

Review 3. Drug therapies for sexually transmitted diseases. Clinical and economic considerations.

Review 4. Chlamydia trachomatis in adolescents and adults. Clinical and economic implications.

5. Persistence of Chlamydia trachomatis is induced by ciprofloxacin and ofloxacin in vitro.

Review 6. Quinolones in sexually transmitted diseases.

Review 7. Quinolones in intracellular infections.

Review 8. Ofloxacin. A reappraisal of its use in the management of genitourinary tract infections.

9. Periodic health examination, 1996 update: 2. Screening for chlamydial infections. Canadian Task Force on the Periodic Health Examination.

Review 10. Quinolones in sexually transmitted diseases. Global experience.