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Literature DB >> 15102826

Pneumococcal surface protein C contributes to sepsis caused by Streptococcus pneumoniae in mice.

Francesco Iannelli¹, Damiana Chiavolini, Susanna Ricci, Marco Rinaldo Oggioni, Gianni Pozzi.

Abstract

The role of pneumococcal surface protein C (PspC; also called SpsA, CbpA, and Hic) in sepsis by Streptococcus pneumoniae was investigated in a murine infection model. The pspC gene was deleted in strains D39 (type 2) and A66 (type 3), and the mutants were tested by being injected intravenously into mice. The animals infected with the mutant strains showed a significant increase in survival, with the 50% lethal dose up to 250-fold higher than that for the wild type. Our findings indicate that PspC affords a decisive contribution to sepsis development.

Entities: Disease Species

Mesh：

Substances：

Year: 2004 PMID： 15102826 PMCID： PMC387904 DOI： 10.1128/IAI.72.5.3077-3080.2004

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

21 in total

1. The polymeric immunoglobulin receptor translocates pneumococci across human nasopharyngeal epithelial cells.

Authors: J R Zhang; K E Mostov; M E Lamm; M Nanno; S Shimida; M Ohwaki; E Tuomanen
Journal: Cell Date: 2000-09-15 Impact factor: 41.582

2. Streptococcus pneumoniae evades complement attack and opsonophagocytosis by expressing the pspC locus-encoded Hic protein that binds to short consensus repeats 8-11 of factor H.

Authors: Hanna Jarva; Robert Janulczyk; Jens Hellwage; Peter F Zipfel; Lars Björck; Seppo Meri
Journal: J Immunol Date: 2002-02-15 Impact factor: 5.422

3. Novel purification scheme and functions for a C3-binding protein from Streptococcus pneumoniae.

Authors: Q Cheng; D Finkel; M K Hostetter
Journal: Biochemistry Date: 2000-05-09 Impact factor: 3.162

4. Contribution of novel choline-binding proteins to adherence, colonization and immunogenicity of Streptococcus pneumoniae.

Authors: C Rosenow; P Ryan; J N Weiser; S Johnson; P Fontan; A Ortqvist; H R Masure
Journal: Mol Microbiol Date: 1997-09 Impact factor: 3.501

5. PspC, a pneumococcal surface protein, binds human factor H.

Authors: S Dave; A Brooks-Walter; M K Pangburn; L S McDaniel
Journal: Infect Immun Date: 2001-05 Impact factor: 3.441

6. Role of genetic resistance in invasive pneumococcal infection: identification and study of susceptibility and resistance in inbred mouse strains.

Authors: N A Gingles; J E Alexander; A Kadioglu; P W Andrew; A Kerr; T J Mitchell; E Hopes; P Denny; S Brown; H B Jones; S Little; G C Booth; W L McPheat
Journal: Infect Immun Date: 2001-01 Impact factor: 3.441

7. Species-specific binding of human secretory component to SpsA protein of Streptococcus pneumoniae via a hexapeptide motif.

Authors: S Hammerschmidt; M P Tillig; S Wolff; J P Vaerman; G S Chhatwal
Journal: Mol Microbiol Date: 2000-05 Impact factor: 3.501

8. Hic, a novel surface protein of Streptococcus pneumoniae that interferes with complement function.

Authors: R Janulczyk; F Iannelli; A G Sjoholm; G Pozzi; L Bjorck
Journal: J Biol Chem Date: 2000-11-24 Impact factor: 5.157

Review 9. Pneumococcal virulence factors: structure and function.

Authors: M J Jedrzejas
Journal: Microbiol Mol Biol Rev Date: 2001-06 Impact factor: 11.056

10. The pspC gene of Streptococcus pneumoniae encodes a polymorphic protein, PspC, which elicits cross-reactive antibodies to PspA and provides immunity to pneumococcal bacteremia.

Authors: A Brooks-Walter; D E Briles; S K Hollingshead
Journal: Infect Immun Date: 1999-12 Impact factor: 3.441

33 in total

1. Pneumolysin, PspA, and PspC contribute to pneumococcal evasion of early innate immune responses during bacteremia in mice.

Authors: Lisa R Quin; Quincy C Moore; Larry S McDaniel
Journal: Infect Immun Date: 2007-01-12 Impact factor: 3.441

2. RR06 activates transcription of spr1996 and cbpA in Streptococcus pneumoniae.

Authors: Zhuo Ma; Jing-Ren Zhang
Journal: J Bacteriol Date: 2007-01-12 Impact factor: 3.490

3. The effects of PspC on complement-mediated immunity to Streptococcus pneumoniae vary with strain background and capsular serotype.

Authors: Jose Yuste; Suneeta Khandavilli; Naadir Ansari; Kairya Muttardi; Laura Ismail; C Hyams; Jeffrey Weiser; Timothy Mitchell; Jeremy S Brown
Journal: Infect Immun Date: 2009-11-02 Impact factor: 3.441

Review 4. Clinical and Experimental Sepsis Impairs CD8 T-Cell-Mediated Immunity.

Authors: Derek B Danahy; Robert K Strother; Vladimir P Badovinac; Thomas S Griffith
Journal: Crit Rev Immunol Date: 2016 Impact factor: 2.214

5. Structural determinants of host specificity of complement Factor H recruitment by Streptococcus pneumoniae.

Authors: David Achila; Aizhuo Liu; Rahul Banerjee; Yue Li; Erik Martinez-Hackert; Jing-Ren Zhang; Honggao Yan
Journal: Biochem J Date: 2015-01-15 Impact factor: 3.857

6. The lack of Pneumococcal surface protein C (PspC) increases the susceptibility of Streptococcus pneumoniae to the killing by microglia.

Authors: Samuele Peppoloni; Bruna Colombari; Rachele Neglia; Daniela Quaglino; Francesco Iannelli; Marco Rinaldo Oggioni; Gianni Pozzi; Elisabetta Blasi
Journal: Med Microbiol Immunol Date: 2005-05-21 Impact factor: 3.402