Literature DB >> 17220305

Pneumolysin, PspA, and PspC contribute to pneumococcal evasion of early innate immune responses during bacteremia in mice.

Lisa R Quin1, Quincy C Moore, Larry S McDaniel.   

Abstract

The pneumococcal virulence factors include capsule, PspA, PspC, and Ply. Cytometric analysis demonstrated that the greatest levels of C3 deposition were on a Deltaply PspA(-) PspC(-) mutant. Also, Ply, PspA, and PspC expression resulted in C3 degradation in vitro and in vivo. Finally, blood clearance assays demonstrated that there was enhanced clearance of Deltaply PspA(-) PspC(-) pneumococci compared to the clearance of nonencapsulated pneumococci.

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Year:  2007        PMID： 17220305      PMCID： PMC1865685          DOI： 10.1128/IAI.01727-06

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  27 in total

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  35 in total

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Review 4.  Pathogenesis and pathophysiology of pneumococcal meningitis.

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Review 6.  Animal models of Streptococcus pneumoniae disease.

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7.  Streptococcus pneumoniae resistance to complement-mediated immunity is dependent on the capsular serotype.

Authors:  Catherine Hyams; Jose Yuste; Katie Bax; Emilie Camberlein; Jeffrey N Weiser; Jeremy S Brown
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