| Literature DB >> 11119534 |
N A Gingles1, J E Alexander, A Kadioglu, P W Andrew, A Kerr, T J Mitchell, E Hopes, P Denny, S Brown, H B Jones, S Little, G C Booth, W L McPheat.
Abstract
From a panel of nine inbred mice strains intranasally infected with Streptococcus pneumoniae type 2 strain, BALB/c mice were resistant and CBA/Ca and SJL mice were susceptible to infection. Further investigation revealed that BALB/c mice were able to prevent proliferation of pneumococci in the lungs and blood, whereas CBA/Ca mice showed no bacterial clearance. Rapidly increasing numbers of bacteria in the blood was a feature of CBA/Ca but not BALB/c mice. In the lungs, BALB/c mice recruited significantly more neutrophils than CBA/Ca mice at 12 and 24 h postinfection. Inflammatory lesions in BALB/c mice were visible much earlier than in CBA/Ca mice, and there was a greater cellular infiltration into the lung tissue of BALB/c mice at the earlier time points. Our data suggest that resistance or susceptibility to intranasal pneumococci may have an association with recruitment and/or function of neutrophils.Entities:
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Year: 2001 PMID： 11119534 PMCID： PMC97900 DOI： 10.1128/IAI.69.1.426-434.2001
Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441