Literature DB >> 15100437

Role of the yeast Rrp1 protein in the dynamics of pre-ribosome maturation.

Edward W Horsey1, Jelena Jakovljevic, Tiffany D Miles, Piyanun Harnpicharnchai, John L Woolford.   

Abstract

The Saccharomyces cerevisiae gene RRP1 encodes an essential, evolutionarily conserved protein necessary for biogenesis of 60S ribosomal subunits. Processing of 27S pre-ribosomal RNA to mature 25S rRNA is blocked and 60S subunits are deficient in the temperature-sensitive rrp1-1 mutant. We have used recent advances in proteomic analysis to examine in more detail the function of Rrp1p in ribosome biogenesis. We show that Rrp1p is a nucleolar protein associated with several distinct 66S pre-ribosomal particles. These pre-ribosomes contain ribosomal proteins plus at least 28 nonribosomal proteins necessary for production of 60S ribosomal subunits. Inactivation of Rrp1p inhibits processing of 27SA(3) to 27SB(S) pre-rRNA and of 27SB pre-rRNA to 7S plus 25.5S pre-rRNA. Thus, in the rrp1-1 mutant, 66S pre-ribosomal particles accumulate that contain 27SA(3) and 27SB(L) pre-ribosomal RNAs.

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Year:  2004        PMID： 15100437      PMCID： PMC1370572          DOI： 10.1261/rna.5255804

Source DB:  PubMed          Journal:  RNA        ISSN： 1355-8382            Impact factor:   4.942


  72 in total

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Journal:  Mol Cell Biol       Date:  1999-02       Impact factor: 4.272

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Journal:  J Cell Sci       Date:  1999-06       Impact factor: 5.285

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Journal:  EMBO J       Date:  1994-07-01       Impact factor: 11.598
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  55 in total

1.  Npa1p, a component of very early pre-60S ribosomal particles, associates with a subset of small nucleolar RNPs required for peptidyl transferase center modification.

Authors:  Christophe Dez; Carine Froment; Jacqueline Noaillac-Depeyre; Bernard Monsarrat; Michèle Caizergues-Ferrer; Yves Henry
Journal:  Mol Cell Biol       Date:  2004-07       Impact factor: 4.272

2.  Mechanism of eIF6-mediated inhibition of ribosomal subunit joining.

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Journal:  J Biol Chem       Date:  2010-03-31       Impact factor: 5.157

3.  Ytm1, Nop7, and Erb1 form a complex necessary for maturation of yeast 66S preribosomes.

Authors:  Tiffany D Miles; Jelena Jakovljevic; Edward W Horsey; Piyanun Harnpicharnchai; Lan Tang; John L Woolford
Journal:  Mol Cell Biol       Date:  2005-12       Impact factor: 4.272

4.  Tracking the interactions of rRNA processing proteins during nucleolar assembly in living cells.

Authors:  Nicole Angelier; Marc Tramier; Emilie Louvet; Maïté Coppey-Moisan; Tula M Savino; Jan R De Mey; Danièle Hernandez-Verdun
Journal:  Mol Biol Cell       Date:  2005-04-06       Impact factor: 4.138

5.  Loc1p is required for efficient assembly and nuclear export of the 60S ribosomal subunit.

Authors:  Carl R Urbinati; Graydon B Gonsalvez; John P Aris; Roy M Long
Journal:  Mol Genet Genomics       Date:  2006-07-27       Impact factor: 3.291

6.  Why molecular chaperones buffer mutational damage: a case study with a yeast Hsp40/70 system.

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Journal:  Genetics       Date:  2006-07-18       Impact factor: 4.562

7.  Assembly factors Rpf2 and Rrs1 recruit 5S rRNA and ribosomal proteins rpL5 and rpL11 into nascent ribosomes.

Authors:  Jingyu Zhang; Piyanun Harnpicharnchai; Jelena Jakovljevic; Lan Tang; Yurong Guo; Marlene Oeffinger; Michael P Rout; Shawna L Hiley; Timothy Hughes; John L Woolford
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8.  Ribosomal proteins L7 and L8 function in concert with six A₃ assembly factors to propagate assembly of domains I and II of 25S rRNA in yeast 60S ribosomal subunits.

Authors:  Jelena Jakovljevic; Uli Ohmayer; Michael Gamalinda; Jason Talkish; Lisa Alexander; Jan Linnemann; Philipp Milkereit; John L Woolford
Journal:  RNA       Date:  2012-08-14       Impact factor: 4.942

9.  Regulation of E2F1-induced apoptosis by the nucleolar protein RRP1B.

Authors:  Jason C Paik; Bing Wang; Kang Liu; Jerry K Lue; Weei-Chin Lin
Journal:  J Biol Chem       Date:  2009-12-29       Impact factor: 5.157

10.  Utilizing gene pair orientations for HMM-based analysis of promoter array ChIP-chip data.

Authors:  Michael Seifert; Jens Keilwagen; Marc Strickert; Ivo Grosse
Journal:  Bioinformatics       Date:  2009-04-28       Impact factor: 6.937
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