Literature DB >> 15099844

Hepatoprotective activity of Trianthema portulacastrum L. against paracetamol and thioacetamide intoxication in albino rats.

G Kumar1, G Sharmila Banu, P Vanitha Pappa, M Sundararajan, M Rajasekara Pandian.   

Abstract

The ethanolic extract of Trianthema portulacastrum L. (Aizoaceae) showed a significant dose dependent (100 mg, 200 mg/kg p.o. 10x) protective effect against paracetamol and thioacetamide induced hepatotoxicity in albino rats. The degree of protection was measured by using biochemical parameters like serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), alkaline phosphatase (ALP), bilirubin (BRN), and total protein (TP). The plant extract completely prevented the toxic effects of paracetamol (acetaminophen) and thioacetamide on the above serum parameters. A significant hepatoprotective activity of the ethanolic extracts of Trianthema portulacastrum L. was reported. Copyright 2003 Elsevier Ireland Ltd.

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Year:  2004        PMID： 15099844     DOI： 10.1016/j.jep.2003.12.009

Source DB:  PubMed          Journal:  J Ethnopharmacol        ISSN： 0378-8741            Impact factor:   4.360


  24 in total

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4.  Ethanolic leaves extract of Trianthema portulacastrum L. ameliorates aflatoxin B(1) induced hepatic damage in rats.

Authors:  G Sharmila Banu; Ganeshan Kumar; A G Murugesan
Journal:  Indian J Clin Biochem       Date:  2009-09-16

5.  Effect of ethanolic leaf extract of Trianthema portulacastrum L. On aflatoxin induced hepatic damage in rats.

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Journal:  Indian J Clin Biochem       Date:  2009-12-30

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8.  Effect of l-ornithine l-aspartate against thioacetamide-induced hepatic damage in rats.

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9.  Protective Role of Phyllanthus niruri Extract against Thioacetamide-Induced Liver Cirrhosis in Rat Model.

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10.  Attenuating effect of Ginkgo biloba leaves extract on liver fibrosis induced by thioacetamide in mice.

Authors:  Atef M Al-Attar
Journal:  J Biomed Biotechnol       Date:  2012-10-02
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