Literature DB >> 23105870

Effect of ethanolic leaf extract of Trianthema portulacastrum L. On aflatoxin induced hepatic damage in rats.

G Sharmila Banu1, G Kumar, A G Murugesan.   

Abstract

The aim of this study was to investigate the ethanolic leaf extract of Trianthema portulacastrum L. (Family: Aizoaceae) on aflatoxin induced hepatic damage in rats. Aflatoxin intoxication in rats significantly (p < 0.001) elevated the levels of serum glutamate pyruvate transaminase (SGPT), serum glutamate oxaloacetate transaminase (SGOT), alkaline phosphatase (ALP), and total bilirubin, which indicated acute hepatocellular damage and biliary obstruction. Ethanolic leaf extract of T. portulacastrum showed dose dependent decrease in the levels of SGPT, SGOT, ALP and total bilirubin. Minimum effective dose of extract was found to be 100 mg/kg body weight. Results obtained from histopathological studies also supported hepatoprotective activity against aflatoxin-induced hepatotoxicity. Thus the study demonstrates that T. portulacastrum possess antihepatotoxic effect against aflatoxin.

Entities:  

Keywords:  Aflatoxin; Antihepatotoxic Effect; Hepatic damage; Trianthema portulacastrum L

Year:  2009        PMID： 23105870      PMCID： PMC3453065          DOI： 10.1007/s12291-009-0074-2

Source DB:  PubMed          Journal:  Indian J Clin Biochem        ISSN： 0970-1915


  11 in total

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Review 1.  Animal models of hepatotoxicity.

Authors:  Ganesh Singh Bhakuni; Onkar Bedi; Jitender Bariwal; Rahul Deshmukh; Puneet Kumar
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3.  Trianthema portulacastrum Linn. displays anti-inflammatory responses during chemically induced rat mammary tumorigenesis through simultaneous and differential regulation of NF-κB and Nrf2 signaling pathways.

Authors:  Animesh Mandal; Anupam Bishayee
Journal:  Int J Mol Sci       Date:  2015-01-22       Impact factor: 5.923

Review 4.  Efficacy and Mechanisms of Flavonoids against the Emerging Opportunistic Nontuberculous Mycobacteria.

Authors:  Suresh Mickymaray; Faiz Abdulaziz Alfaiz; Anand Paramasivam
Journal:  Antibiotics (Basel)       Date:  2020-07-27

5.  In vitro Antioxidant Activities of Trianthema portulacastrum L. Hydrolysates.

Authors:  Sadaf Yaqoob; Bushra Sultana; Muhammad Mushtaq
Journal:  Prev Nutr Food Sci       Date:  2014-01
  5 in total

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