Literature DB >> 15081025

Structural determinants for high 5-HT(2A) receptor affinity of spiro[9,10-dihydroanthracene]-9,3(')-pyrrolidine (SpAMDA).

Srinivas Peddi1, Bryan L Roth, Richard A Glennon, Richard B Westkaemper.   

Abstract

The synthesis and 5-HT(2A) receptor affinities of ring altered derivatives of spiro[9,10-dihydroanthracene]-9,3(')-pyrrolidine (4), a structurally unique tetracyclic 5-HT(2A) receptor antagonist, are described. The characteristics of the parent compound prove to be necessary for optimal 5-HT(2A) receptor affinity. However, expansion of the size of the pyrrolidine and central rings produce compounds with reasonably high 5-HT(2A) receptor affinities. In addition, the parent compound is shown to have high 5-HT(2) receptor selectivity.

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Year:  2004        PMID： 15081025     DOI： 10.1016/j.bmcl.2004.02.014

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  10 in total

1.  Ethyl (E)-3-[1'-ethyl-2-oxo-4'-(phenyl-sulfon-yl)-2H-spiro-[acenaphthyl-ene-1,2'-pyrrolidine]-3'-yl]acrylate.

Authors:  Ulaganathan Sankar; R Uma; S Sundaramoorthy; D Velmurugan
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-04-18

2.  Methyl 5''-chloro-1',1''-dimethyl-2,2''-dioxodi-spiro-[indoline-3,2'-pyrrolidine-3',3''-indoline]-4'-carboxyl-ate.

Authors:  Piskala Subburaman Kannan; Panneerselvam Yuvaraj; Karthikeyan Manivannan; Boreddy Siva Rami Reddy; Arunachalathevar Subbiahpandi
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2013-05-04

3.  1',1''-Dimethyl-4'-(naphthalen-1-yl)-1,2,3,4-tetra-hydro-naphthalene-2-spiro-3'-pyrrolidine-2'-spiro-3''-indoline-1,2''-dione.

Authors:  S Selvanayagam; K Ravikumar; P Saravanan; R Raghunathan
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-03-02

4.  Antidepressant potential of nitrogen-containing heterocyclic moieties: An updated review.

Authors:  Nadeem Siddiqui; Sandhya Bawa; Ruhi Ali; Obaid Afzal; M Jawaid Akhtar; Bishmillah Azad; Rajiv Kumar
Journal:  J Pharm Bioallied Sci       Date:  2011-04

5.  Methyl 3'-benzyl-4'-(2,4-di-chloro-phen-yl)-1'-methyl-2-oxo-1-propyl-spiro-[indoline-3,2'-pyrrolidine]-3'-carboxy-l-ate.

Authors:  S Karthikeyan; K Sethusankar; Anthonisamy Devaraj; Manickam Bakthadoss
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2014-02-12

6.  Crystal structure of ethyl 2'',3-dioxo-7',7a'-di-hydro-1'H,3H,3'H-di-spiro[benzo[b]thio-phene-2,6'-pyrrolo-[1,2-c]thia-zole-5',3''-indoline]-7'-carboxyl-ate.

Authors:  M P Savithri; M Suresh; R Raghunathan; R Raja; A SubbiahPandi
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2015-02-07

Review 7.  Multitargeting nature of muscarinic orthosteric agonists and antagonists.

Authors:  Jaromir Myslivecek
Journal:  Front Physiol       Date:  2022-09-06       Impact factor: 4.755

8.  Methyl (3R*,3'S*)-1',1''-dimethyl-2,2''-dioxodispiro-[indoline-3,2'-pyrrolidine-3',3''-indoline]-4'-carboxyl-ate.

Authors:  G Ganesh; Panneer Selvam Yuvaraj; E Govindan; Boreddy S R Reddy; A Subbiahpandi
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-09-08

9.  Ethyl 27-oxo-15-oxa-2,20-diaza-hexa-cyclo-[18.6.1.0(1,8).0(2,6).0(9,14).0(21,26)]hepta-cosa-9,11,13,21,23,25-hexa-ene-7-carboxyl-ate.

Authors:  Sibi Narayanan; Thothadri Srinivasan; Santhanagopalan Purushothaman; Raghavachary Raghunathan; Devadasan Velmurugan
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-12-05

10.  Dibenzofuranylethylamines as 5-HT2A/2C Receptor Agonists.

Authors:  Thirumal Yempala; José Brea; María Isabel Loza; Douglas J Matthies; Gerald Zapata-Torres; Bruce K Cassels
Journal:  ACS Omega       Date:  2020-01-27
  10 in total

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