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Literature DB >> 15078971

Transduction of terminally differentiated neurons by avian sarcoma virus.

James G Greger¹, Richard A Katz, Konstantin Taganov, Glenn F Rall, Anna Marie Skalka.

Abstract

Recent studies have demonstrated that avian sarcoma virus (ASV) can transduce cycle-arrested cells. Here, we have assessed quantitatively the transduction efficiency of an ASV vector in naturally arrested mouse hippocampal neurons. This efficiency was determined by comparing the number of transduced cells after infection of differentiated neurons versus dividing progenitor cells. The results indicate that ASV is able to transduce these differentiated neurons efficiently and that this activity is not the result of infection of residual dividing cells. The transduction efficiency of the ASV vector was found to be intermediate between the relatively high and low efficiencies obtained with human immunodeficiency virus type 1 and murine leukemia virus vectors, respectively.

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Year: 2004 PMID： 15078971 PMCID： PMC387698 DOI： 10.1128/jvi.78.9.4902-4906.2004

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

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