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Literature DB >> 9420292

Minimal requirement for a lentivirus vector based on human immunodeficiency virus type 1.

V N Kim¹, K Mitrophanous, S M Kingsman, A J Kingsman.

Abstract

The use of human immunodeficiency virus vectors for gene therapy is hampered by concern over their safety. This concern might be ameliorated, in part, if the viral accessory genes and proteins could be eliminated from the vector genomes and particles. Here we describe a minimal vector system that is capable of transducing nondividing cells and which does not contain tat, vif, vpr, vpu, and nef.

Entities: Gene Species

Mesh：

Substances：

Year: 1998 PMID： 9420292 PMCID： PMC109441

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

58 in total

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Journal: J Virol Date: 1992-05 Impact factor: 5.103

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Authors: M Bray; S Prasad; J W Dubay; E Hunter; K T Jeang; D Rekosh; M L Hammarskjöld
Journal: Proc Natl Acad Sci U S A Date: 1994-02-15 Impact factor: 11.205

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Authors: J Gulizia; M P Dempsey; N Sharova; M I Bukrinsky; L Spitz; D Goldfarb; M Stevenson
Journal: J Virol Date: 1994-03 Impact factor: 5.103

4. The Tat protein of human immunodeficiency virus type 1, a growth factor for AIDS Kaposi sarcoma and cytokine-activated vascular cells, induces adhesion of the same cell types by using integrin receptors recognizing the RGD amino acid sequence.

Authors: G Barillari; R Gendelman; R C Gallo; B Ensoli
Journal: Proc Natl Acad Sci U S A Date: 1993-09-01 Impact factor: 11.205

5. Inhibition of human immunodeficiency virus type 1 replication by regulated expression of a polymeric Tat activation response RNA decoy as a strategy for gene therapy in AIDS.

Authors: J Lisziewicz; D Sun; J Smythe; P Lusso; F Lori; A Louie; P Markham; J Rossi; M Reitz; R C Gallo
Journal: Proc Natl Acad Sci U S A Date: 1993-09-01 Impact factor: 11.205

6. Vif is crucial for human immunodeficiency virus type 1 proviral DNA synthesis in infected cells.

Authors: U von Schwedler; J Song; C Aiken; D Trono
Journal: J Virol Date: 1993-08 Impact factor: 5.103

7. Induction of cell differentiation by human immunodeficiency virus 1 vpr.

Authors: D N Levy; L S Fernandes; W V Williams; D B Weiner
Journal: Cell Date: 1993-02-26 Impact factor: 41.582

8. A nuclear localization signal within HIV-1 matrix protein that governs infection of non-dividing cells.

Authors: M I Bukrinsky; S Haggerty; M P Dempsey; N Sharova; A Adzhubel; L Spitz; P Lewis; D Goldfarb; M Emerman; M Stevenson
Journal: Nature Date: 1993-10-14 Impact factor: 69.504

9. The human immunodeficiency virus-1 nef gene product: a positive factor for viral infection and replication in primary lymphocytes and macrophages.

Authors: M D Miller; M T Warmerdam; I Gaston; W C Greene; M B Feinberg
Journal: J Exp Med Date: 1994-01-01 Impact factor: 14.307

10. The importance of nef in the induction of human immunodeficiency virus type 1 replication from primary quiescent CD4 lymphocytes.

Authors: C A Spina; T J Kwoh; M Y Chowers; J C Guatelli; D D Richman
Journal: J Exp Med Date: 1994-01-01 Impact factor: 14.307

59 in total

1. A lentivirus packaging system based on alternative RNA transport mechanisms to express helper and gene transfer vector RNAs and its use to study the requirement of accessory proteins for particle formation and gene delivery.

Authors: N Srinivasakumar; F G Schuening
Journal: J Virol Date: 1999-11 Impact factor: 5.103

2. Inhibition of human immunodeficiency virus type 1 (HIV-1) replication by HIV-1-based lentivirus vectors expressing transdominant Rev.

Authors: M R Mautino; N Keiser; R A Morgan
Journal: J Virol Date: 2001-04 Impact factor: 5.103

3. Separable mechanisms of attachment and cell uptake during retrovirus infection.

Authors: S Sharma; A Miyanohara; T Friedmann
Journal: J Virol Date: 2000-11 Impact factor: 5.103

4. Translation is not required To generate virion precursor RNA in human immunodeficiency virus type 1-infected T cells.

Authors: M Butsch; K Boris-Lawrie
Journal: J Virol Date: 2000-12 Impact factor: 5.103

Review 5. Viral vectors for in vivo gene transfer in Parkinson's disease: properties and clinical grade production.

Authors: Ronald J Mandel; Corinna Burger; Richard O Snyder
Journal: Exp Neurol Date: 2007-08-24 Impact factor: 5.330

Review 6. Integration-deficient lentiviral vectors: a slow coming of age.

Authors: Klaus Wanisch; Rafael J Yáñez-Muñoz
Journal: Mol Ther Date: 2009-06-02 Impact factor: 11.454

Review 7. Lentiviral vector-mediated RNA silencing in the central nervous system.

Authors: Thomas H Hutson; Edmund Foster; Lawrence D F Moon; Rafael J Yáñez-Muñoz
Journal: Hum Gene Ther Methods Date: 2013-11-01 Impact factor: 2.396

8. Transgene expression in the mouse cerebellar Purkinje cells with a minimal level of integration using long terminal repeat-modified lentiviral vectors.

Authors: Kiyohiko Takayama; Takashi Torashima
Journal: J Neurovirol Date: 2009-09 Impact factor: 2.643

9. Transduction of terminally differentiated neurons by avian sarcoma virus.

Authors: James G Greger; Richard A Katz; Konstantin Taganov; Glenn F Rall; Anna Marie Skalka
Journal: J Virol Date: 2004-05 Impact factor: 5.103

10. Requirements for efficient production and transduction of human immunodeficiency virus type 1-based vectors.

Authors: M Gasmi; J Glynn; M J Jin; D J Jolly; J K Yee; S T Chen
Journal: J Virol Date: 1999-03 Impact factor: 5.103