Literature DB >> 15059825

A database for management of gene expression data in situ.

Ekaterina Poustelnikova1, Andrei Pisarev, Maxim Blagov, Maria Samsonova, John Reinitz.   

Abstract

MOTIVATION: To create a spatiotemporal atlas of Drosophila segmentation gene expression at cellular resolution.
RESULTS: The expression of segmentation genes plays a crucial role in the establishment of the Drosophila body plan. Using the IBM DB2 Relational Database Management System we have designed and implemented the FlyEx database. FlyEx contains 2832 images of 14 segmentation gene expression patterns obtained from 954 embryos and 2,073,662 quantitative data records. The averaged data is available for most of segmentation genes at eight time points. FlyEx supports operations on images of gene expression patterns. The database can be used to examine the quality of data, analyze the dynamics of formation of segmentation gene expression domains, as well as estimate the variability of gene expression patterns. We also provide the capability to download data of interest. AVAILABILITY: http://urchin.spbcas.ru/flyex, http://flyex.ams.sunysb.edu/flyex

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Year:  2004        PMID: 15059825     DOI: 10.1093/bioinformatics/bth222

Source DB:  PubMed          Journal:  Bioinformatics        ISSN: 1367-4803            Impact factor:   6.937


  55 in total

1.  Measuring gene expression noise in early Drosophila embryos: nucleus-to-nucleus variability.

Authors:  Nina E Golyandina; David M Holloway; Francisco J P Lopes; Alexander V Spirov; Ekaterina N Spirova; Konstantin D Usevich
Journal:  Procedia Comput Sci       Date:  2012-06-02

2.  Bicoid cooperative DNA binding is critical for embryonic patterning in Drosophila.

Authors:  Danielle Lebrecht; Marisa Foehr; Eric Smith; Francisco J P Lopes; Carlos E Vanario-Alonso; John Reinitz; David S Burz; Steven D Hanes
Journal:  Proc Natl Acad Sci U S A       Date:  2005-09-06       Impact factor: 11.205

3.  Characterization of the Drosophila segment determination morphome.

Authors:  Svetlana Surkova; David Kosman; Konstantin Kozlov; Ekaterina Myasnikova; Anastasia A Samsonova; Alexander Spirov; Carlos E Vanario-Alonso; Maria Samsonova; John Reinitz
Journal:  Dev Biol       Date:  2007-11-04       Impact factor: 3.582

4.  Estimation of errors introduced by confocal imaging into the data on segmentation gene expression in Drosophila.

Authors:  Ekaterina Myasnikova; Svetlana Surkova; Lena Panok; Maria Samsonova; John Reinitz
Journal:  Bioinformatics       Date:  2008-12-03       Impact factor: 6.937

5.  Determining the scale of the Bicoid morphogen gradient.

Authors:  Inbal Hecht; Wouter-Jan Rappel; Herbert Levine
Journal:  Proc Natl Acad Sci U S A       Date:  2009-02-03       Impact factor: 11.205

Review 6.  Pipeline for acquisition of quantitative data on segmentation gene expression from confocal images.

Authors:  Svetlana Surkova; Ekaterina Myasnikova; Hilde Janssens; Konstantin N Kozlov; Anastasia A Samsonova; John Reinitz; Maria Samsonova
Journal:  Fly (Austin)       Date:  2008-03-08       Impact factor: 2.160

7.  Ancestral resurrection of the Drosophila S2E enhancer reveals accessible evolutionary paths through compensatory change.

Authors:  Carlos Martinez; Joshua S Rest; Ah-Ram Kim; Michael Ludwig; Martin Kreitman; Kevin White; John Reinitz
Journal:  Mol Biol Evol       Date:  2014-01-09       Impact factor: 16.240

8.  Statistical mechanics of Monod-Wyman-Changeux (MWC) models.

Authors:  Sarah Marzen; Hernan G Garcia; Rob Phillips
Journal:  J Mol Biol       Date:  2013-03-14       Impact factor: 5.469

9.  The role of Bicoid cooperative binding in the patterning of sharp borders in Drosophila melanogaster.

Authors:  Francisco J P Lopes; Alexander V Spirov; Paulo M Bisch
Journal:  Dev Biol       Date:  2012-07-25       Impact factor: 3.582

10.  Dual regulation by the Hunchback gradient in the Drosophila embryo.

Authors:  Dmitri Papatsenko; Michael S Levine
Journal:  Proc Natl Acad Sci U S A       Date:  2008-02-19       Impact factor: 11.205

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