Literature DB >> 1505772

Dosing problems in the use of topical ophthalmic drops.

A Loewenstein1, O Geyer, A Blanc, M Lazar.   

Abstract

The effect of two drops of the same drug, one instilled immediately after the other, was compared to the effect of a single drop in 100 healthy volunteers. The drugs investigated were tropicamide, 0.125%, and phenylephrine, 2.5%. The mydriatic effect of two drops was 30%-35% stronger than the effect achieved by a single drop.

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Year:  1992        PMID： 1505772     DOI： 10.1007/bf00165949

Source DB:  PubMed          Journal:  Graefes Arch Clin Exp Ophthalmol        ISSN： 0721-832X            Impact factor:   3.117


  6 in total

1.  Ocular penetration of pilocarpine: The effect of multiple doses on the ocular penetration of pilocarpine.

Authors:  R M Ramer; A R Gasset
Journal:  Ann Ophthalmol       Date:  1975-01

2.  Drop size of commercial glaucoma medications.

Authors:  C M Lederer; R E Harold
Journal:  Am J Ophthalmol       Date:  1986-06-15       Impact factor: 5.258

3.  Drop size and initial dosing frequency problems of topically applied ophthalmic drugs.

Authors:  S S Chrai; M C Makoid; S P Eriksen; J R Robinson
Journal:  J Pharm Sci       Date:  1974-03       Impact factor: 3.534

4.  Loading doses and extended dosing intervals in topical gentamicin therapy.

Authors:  D B Glasser; S Gardner; J G Ellis; T H Pettit
Journal:  Am J Ophthalmol       Date:  1985-03-15       Impact factor: 5.258

Review 5.  Clinical pharmacokinetics of the eye. Proctor lecture.

Authors:  S Mishima
Journal:  Invest Ophthalmol Vis Sci       Date:  1981-10       Impact factor: 4.799

6.  Determination of tear volume and tear flow.

Authors:  S Mishima; A Gasset; S D Klyce; J L Baum
Journal:  Invest Ophthalmol       Date:  1966-06
  6 in total
  2 in total

1.  The effect of nasolacrimal occlusion on drug-induced mydriasis.

Authors:  A Loewenstein; A Sadeh; M Goldstein; M Lazar
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  1995-08       Impact factor: 3.117

2.  Application of eye drops to the medial canthus.

Authors:  A Loewenstein; S Bolocinic; M Goldstein; M Lazar
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  1994-11       Impact factor: 3.117
  2 in total

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