BACKGROUND: Our purpose was to investigate the efficacy of instillation of eye drops in the medial canthus with the lids closed at the time of application. METHODS: The pupils of 50 healthy volunteers were dilated with tropicamide 0.125%. The effect of the drug on pupillary dilatation when instilled in one eye with the lids closed was compared to its effect when instilled in the conventional mode in the other eye. RESULTS: Maximal mydriasis achieved was 2.75 +/- 0.76 mm in the eye with closed lids and 2.8 +/- 0.77 mm in the eye in which eye drops were instilled in the conventional mode. CONCLUSION: Eye drop instillation in the medial canthus with the lids closed at the time of application seems to be an effective means of ophthalmic drug delivery.
BACKGROUND: Our purpose was to investigate the efficacy of instillation of eye drops in the medial canthus with the lids closed at the time of application. METHODS: The pupils of 50 healthy volunteers were dilated with tropicamide 0.125%. The effect of the drug on pupillary dilatation when instilled in one eye with the lids closed was compared to its effect when instilled in the conventional mode in the other eye. RESULTS: Maximal mydriasis achieved was 2.75 +/- 0.76 mm in the eye with closed lids and 2.8 +/- 0.77 mm in the eye in which eye drops were instilled in the conventional mode. CONCLUSION: Eye drop instillation in the medial canthus with the lids closed at the time of application seems to be an effective means of ophthalmic drug delivery.