Literature DB >> 15050044

Anticonvulsant activity of Schiff bases of isatin derivatives.

Manjusha Verma1, Surendra Nath Pandeya, Krishna Nand Singh, James P Stables.   

Abstract

Schiff bases of N-methyl and N-acetyl isatin derivatives with different aryl amines have been synthesized and screened for anticonvulsant activities against maximal electroshock (MES) and subcutaneous metrazole (ScMet). N-methyl-5-bromo-3-(p-chlorophenylimino) isatin (2) exhibited anticonvulsant activity in MES and ScMet with LD50 > 600 mg kg(-1), showing better activity than the standard drugs phenytoin, carbamazepine and valproic acid. Thus, compound 2 may be chosen as a prototype for development of new anticonvulsants.

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Year:  2004        PMID： 15050044

Source DB:  PubMed          Journal:  Acta Pharm        ISSN： 1330-0075            Impact factor:   2.230


  39 in total

1.  QM study and conformational analysis of an isatin Schiff base as a potential cytotoxic agent.

Authors:  Ramin Miri; Nima Razzaghi-asl; Mohammad K Mohammadi
Journal:  J Mol Model       Date:  2012-09-29       Impact factor: 1.810

2.  Methyl 2-acetamido-2-(1-acetyl-3-hydr-oxy-2-oxoindolin-3-yl)propanoate.

Authors:  Hoong-Kun Fun; Jia Hao Goh; Yang Liu; Yan Zhang
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-03-03

3.  Synthesis, characterization and anticancer activity of certain 3-{4-(5-mercapto-1,3,4-oxadiazole-2-yl)phenylimino}indolin-2-one derivatives.

Authors:  Rajyalakshmi Gudipati; Rama Narsimha Reddy Anreddy; Sarangapani Manda
Journal:  Saudi Pharm J       Date:  2011-03-11       Impact factor: 4.330

4.  Synthesis, antibacterial, antifungal and antiviral activity evaluation of some new bis-Schiff bases of isatin and their derivatives.

Authors:  Aliasghar Jarrahpour; Dariush Khalili; Erik De Clercq; Chanaz Salmi; Jean Michel Brunel
Journal:  Molecules       Date:  2007-08-07       Impact factor: 4.411

5.  Mechanistic insight of cell anti-proliferative activity of fluoroquinolone drug-based Cu(II) complexes.

Authors:  Divyang H Gandhi; Foram U Vaidya; Chandramani Pathak; Tushar N Patel; Bhupesh S Bhatt
Journal:  Mol Divers       Date:  2021-03-01       Impact factor: 2.943

6.  1-{(E)-[(2-Fluoro-5-nitro-phen-yl)imino]-meth-yl}naphthalen-2-ol.

Authors:  Alan R Kennedy; Mehmet Akkurt; Antar A Abdelhamid; Shaaban K Mohamed; Gary J Miller
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2013-05-11

7.  Isatin Counteracts Diethylnitrosamine/2-Acetylaminofluorene-Induced Hepatocarcinogenesis in Male Wistar Rats by Upregulating Anti-Inflammatory, Antioxidant, and Detoxification Pathways.

Authors:  Nagwa G Tawfik; Wafaa R Mohamed; Hanan S Mahmoud; Mohammed A Alqarni; Ibrahim A Naguib; Alzhraa M Fahmy; Osama M Ahmed
Journal:  Antioxidants (Basel)       Date:  2022-04-01

8.  Biological targets for isatin and its analogues: Implications for therapy.

Authors:  Alexei Medvedev; Olga Buneeva; Vivette Glover
Journal:  Biologics       Date:  2007-06

9.  Antiproliferative activity of novel isatinyl/indanyl nitrones (INs) as potential spin trapping agents of free radical intermediates.

Authors:  Loredana Maiuolo; Giordana Feriotto; Vincenzo Algieri; Monica Nardi; Beatrice Russo; Maria Luisa Di Gioia; Emilia Furia; Matteo Antonio Tallarida; Carlo Mischiati; Antonio De Nino
Journal:  Medchemcomm       Date:  2017-12-20       Impact factor: 3.597

10.  Induction of anxiolytic, antidepressant and analgesic effects by Shiff base of (E)-3-(1H-imidazol-4-yl)-2-((2-oxoindolin-3-ylidene)amino)propanoic acid derivatives in diabetic rats.

Authors:  Mohaddese Goleij; Leila Youseftabar-Miri; Maryam Montazeri; Fatemeh Khakpai
Journal:  J Diabetes Metab Disord       Date:  2021-01-03
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