| Literature DB >> 15036649 |
Klaus Jung1, Carsten Stephan, Michaela Lewandowski, Silke Klotzek, Monika Jung, Glen Kristiansen, Michael Lein, Stefan A Loening, Dietmar Schnorr.
Abstract
We compared the plasma DNA concentrations in patients with different prostate cancer (PCa) stages and with benign prostate hyperplasia (BPH) and in healthy persons. Patients with localized cancer had DNA plasma within the reference interval. Increased plasma DNA was found in patients with lymph node and distant metastases and also in BPH. The association between plasma DNA and the survival time was similarly strong as with prostate-specific antigen. It can be concluded that plasma DNA has a limited validity as metastatic marker in PCa patients but follow-up studies combined with the investigation of tumor-related characteristics of plasma DNA would be reasonable.Entities:
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Year: 2004 PMID： 15036649 DOI： 10.1016/j.canlet.2003.11.023
Source DB: PubMed Journal: Cancer Lett ISSN： 0304-3835 Impact factor: 8.679