| Literature DB >> 15033436 |
Kazuo Kitagawa1, Masayasu Matsumoto, Masatsugu Hori.
Abstract
Cerebral ischemia induces 5-lipoxygenase translocation and leukotriene production in the brain. We tried to clarify the pathological significance of 5-lipoxygenase on cerebral ischemia using 5-lipoxygenase knockout mice. No significant difference was observed in the infarct size following permanent and transient ischemia for 60 min between both types of mice. The present study did not support the idea that leukotriene production is involved in infarct expansion in focal cerebral ischemia.Entities:
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Year: 2004 PMID： 15033436 DOI： 10.1016/j.brainres.2004.01.018
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252