| Literature DB >> 31562627 |
Yi Zheng1, Yu Liu2, Hulya Karatas3, Kazim Yigitkanli4, Theodore R Holman5, Klaus van Leyen6.
Abstract
Ischemic strokes are caused by one or more blood clots that typically obstruct one of the major arteries in the brain, but frequently also result in leakage of the blood-brain barrier and subsequent hemorrhage. While it has long been known that the enzyme 12/15-lipoxygenase (12/15-LOX) is up-regulated following ischemic strokes and contributes to neuronal cell death, recent research has shown an additional major role for 12/15-LOX in causing this hemorrhagic transformation. These findings have important implications for the use of 12/15-LOX inhibitors in the treatment of stroke.Entities:
Keywords: 12-HETE; 15-HETE; Blood-brain barrier; Eicosanoid; Hemorrhage; Hemorrhagic transformation; Ischemia; Ischemic stroke; Lipoxygenase; Neuroprotection; STAT6; Tissue plasminogen activator; Warfarin; tPA
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Year: 2019 PMID： 31562627 PMCID： PMC7278041 DOI： 10.1007/978-3-030-21735-8_12
Source DB: PubMed Journal: Adv Exp Med Biol ISSN： 0065-2598 Impact factor: 2.622