| Literature DB >> 15009433 |
Manuela Flórido1, Ana Sofia Gonçalves, M Salomé Gomes, Rui Appelberg.
Abstract
C57Bl/6 mice and mice deficient in the CD40 molecule were infected with three strains of Mycobacterium avium. Two of the M. avium strains proliferated more extensively in CD40-deficient (CD40-/-) mice than in control mice. The increased susceptibility to infection of CD40-/- mice was associated with the generation of poorer interleukin-12 (IL-12) p40 and interferon-gamma (IFN-gamma) responses as compared to the controls, suggesting a role for CD40 in the development of protective immunity. In contrast, direct triggering of CD40 on infected macrophages failed to induce any anti-mycobacterial activity in infected macrophages.Entities:
Mesh:
Substances:
Year: 2004 PMID: 15009433 PMCID: PMC1782428 DOI: 10.1111/j.1365-2567.2004.01812.x
Source DB: PubMed Journal: Immunology ISSN: 0019-2805 Impact factor: 7.397