Literature DB >> 12064697

Hyper-IgM syndrome with systemic tuberculosis.

Isao Ito1, Tadashi Ishida, Toru Hashimoto, Machiko Arita, Makoto Osawa, Michiaki Mishima, Shigeaki Nonoyama.   

Abstract

A 33-y-old man with Hyper-IgM syndrome developed a severe tuberculous disease complicated by pleuritis and spondylitis. An abnormally decreased CD4/CD8 ratio, decreased CD4 + T-cell count and depressed natural killer cell activity implicated a coexistent cell-mediated immunodeficiency. To our knowledge, this is the first detailed report of tuberculosis associated with Hyper-IgM syndrome.

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Year:  2002        PMID: 12064697     DOI: 10.1080/00365540110080151

Source DB:  PubMed          Journal:  Scand J Infect Dis        ISSN: 0036-5548


  1 in total

1.  CD40 is required for the optimal induction of protective immunity to Mycobacterium avium.

Authors:  Manuela Flórido; Ana Sofia Gonçalves; M Salomé Gomes; Rui Appelberg
Journal:  Immunology       Date:  2004-03       Impact factor: 7.397

  1 in total

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