Literature DB >> 15007140

Association of APOE polymorphisms with disease severity in MS is limited to women.

O H Kantarci1, D D Hebrink, S J Achenbach, S J Pittock, A Altintas, J L Schaefer-Klein, E J Atkinson, M De Andrade, C T McMurray, M Rodriguez, B G Weinshenker.   

Abstract

The authors studied the association of an exon 4 (E4*epsilon2/3/4) and three promoter polymorphisms of APOE with disease course and severity stratified by gender in 221 patients with multiple sclerosis from two overlapping population-based prevalence cohorts. Women carriers of the E4*epsilon2 allele took longer to attain an Expanded Disability Status Scale score of 6 (p = 0.015) and had more favorable ranked severity scores than noncarriers (p = 0.009). There was no association in men. Alleles epsilon3 or epsilon4 and promoter polymorphisms were not associated with disease course or severity.

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Year:  2004        PMID： 15007140     DOI： 10.1212/01.wnl.0000113721.83287.83

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


  14 in total

1.  APOE epsilon4 and the cognitive genetics of multiple sclerosis.

Authors:  O Ghaffar; M Reis; N Pennell; P O'Connor; A Feinstein
Journal:  Neurology       Date:  2010-05-18       Impact factor: 9.910

2.  Onset of progressive phase is an age-dependent clinical milestone in multiple sclerosis.

Authors:  Melih Tutuncu; Junger Tang; Nuhad Abou Zeid; Nilufer Kale; Daniel J Crusan; Elizabeth J Atkinson; Aksel Siva; Sean J Pittock; Istvan Pirko; B Mark Keegan; Claudia F Lucchinetti; John H Noseworthy; Moses Rodriguez; Brian G Weinshenker; Orhun H Kantarci
Journal:  Mult Scler       Date:  2012-06-26       Impact factor: 6.312

Review 3.  Recent advances in the neuroimaging of multiple sclerosis.

Authors:  William D Rooney; Patricia K Coyle
Journal:  Curr Neurol Neurosci Rep       Date:  2005-05       Impact factor: 5.081

4.  Sex and gender issues in multiple sclerosis.

Authors:  Hanne F Harbo; Ralf Gold; Mar Tintoré
Journal:  Ther Adv Neurol Disord       Date:  2013-07       Impact factor: 6.570

Review 5.  The immune-modulatory role of apolipoprotein E with emphasis on multiple sclerosis and experimental autoimmune encephalomyelitis.

Authors:  Hong-Liang Zhang; Jiang Wu; Jie Zhu
Journal:  Clin Dev Immunol       Date:  2010-05-31

6.  ApoE alleles, depression and positive affect in multiple sclerosis.

Authors:  L J Julian; L Vella; D Frankel; S L Minden; J R Oksenberg; D C Mohr
Journal:  Mult Scler       Date:  2009-03       Impact factor: 6.312

7.  Function and comorbidities of apolipoprotein e in Alzheimer's disease.

Authors:  Valérie Leduc; Dorothée Domenger; Louis De Beaumont; Daphnée Lalonde; Stéphanie Bélanger-Jasmin; Judes Poirier
Journal:  Int J Alzheimers Dis       Date:  2011-04-05

Review 8.  Role of Apolipoproteins and α-Synuclein in Parkinson's Disease.

Authors:  Fatemeh Nouri Emamzadeh
Journal:  J Mol Neurosci       Date:  2017-07-10       Impact factor: 3.444

9.  Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.

Authors:  Folkert W Asselbergs; Yiran Guo; Erik P A van Iperen; Suthesh Sivapalaratnam; Vinicius Tragante; Matthew B Lanktree; Leslie A Lange; Berta Almoguera; Yolande E Appelman; John Barnard; Jens Baumert; Amber L Beitelshees; Tushar R Bhangale; Yii-Der Ida Chen; Tom R Gaunt; Yan Gong; Jemma C Hopewell; Toby Johnson; Marcus E Kleber; Taimour Y Langaee; Mingyao Li; Yun R Li; Kiang Liu; Caitrin W McDonough; Matthijs F L Meijs; Rita P S Middelberg; Kiran Musunuru; Christopher P Nelson; Jeffery R O'Connell; Sandosh Padmanabhan; James S Pankow; Nathan Pankratz; Suzanne Rafelt; Ramakrishnan Rajagopalan; Simon P R Romaine; Nicholas J Schork; Jonathan Shaffer; Haiqing Shen; Erin N Smith; Sam E Tischfield; Peter J van der Most; Jana V van Vliet-Ostaptchouk; Niek Verweij; Kelly A Volcik; Li Zhang; Kent R Bailey; Kristian M Bailey; Florianne Bauer; Jolanda M A Boer; Peter S Braund; Amber Burt; Paul R Burton; Sarah G Buxbaum; Wei Chen; Rhonda M Cooper-Dehoff; L Adrienne Cupples; Jonas S deJong; Christian Delles; David Duggan; Myriam Fornage; Clement E Furlong; Nicole Glazer; John G Gums; Claire Hastie; Michael V Holmes; Thomas Illig; Susan A Kirkland; Mika Kivimaki; Ronald Klein; Barbara E Klein; Charles Kooperberg; Kandice Kottke-Marchant; Meena Kumari; Andrea Z LaCroix; Laya Mallela; Gurunathan Murugesan; Jose Ordovas; Willem H Ouwehand; Wendy S Post; Richa Saxena; Hubert Scharnagl; Pamela J Schreiner; Tina Shah; Denis C Shields; Daichi Shimbo; Sathanur R Srinivasan; Ronald P Stolk; Daniel I Swerdlow; Herman A Taylor; Eric J Topol; Elina Toskala; Joost L van Pelt; Jessica van Setten; Salim Yusuf; John C Whittaker; A H Zwinderman; Sonia S Anand; Anthony J Balmforth; Gerald S Berenson; Connie R Bezzina; Bernhard O Boehm; Eric Boerwinkle; Juan P Casas; Mark J Caulfield; Robert Clarke; John M Connell; Karen J Cruickshanks; Karina W Davidson; Ian N M Day; Paul I W de Bakker; Pieter A Doevendans; Anna F Dominiczak; Alistair S Hall; Catharina A Hartman; Christian Hengstenberg; Hans L Hillege; Marten H Hofker; Steve E Humphries; Gail P Jarvik; Julie A Johnson; Bernhard M Kaess; Sekar Kathiresan; Wolfgang Koenig; Debbie A Lawlor; Winfried März; Olle Melander; Braxton D Mitchell; Grant W Montgomery; Patricia B Munroe; Sarah S Murray; Stephen J Newhouse; N Charlotte Onland-Moret; Neil Poulter; Bruce Psaty; Susan Redline; Stephen S Rich; Jerome I Rotter; Heribert Schunkert; Peter Sever; Alan R Shuldiner; Roy L Silverstein; Alice Stanton; Barbara Thorand; Mieke D Trip; Michael Y Tsai; Pim van der Harst; Ellen van der Schoot; Yvonne T van der Schouw; W M Monique Verschuren; Hugh Watkins; Arthur A M Wilde; Bruce H R Wolffenbuttel; John B Whitfield; G Kees Hovingh; Christie M Ballantyne; Cisca Wijmenga; Muredach P Reilly; Nicholas G Martin; James G Wilson; Daniel J Rader; Nilesh J Samani; Alex P Reiner; Robert A Hegele; John J P Kastelein; Aroon D Hingorani; Philippa J Talmud; Hakon Hakonarson; Clara C Elbers; Brendan J Keating; Fotios Drenos
Journal:  Am J Hum Genet       Date:  2012-10-11       Impact factor: 11.025

10.  Investigation of sex-specific effects of apolipoprotein E on severity of EAE and MS.

Authors:  L Schrewe; C M Lill; T Liu; A Salmen; L A Gerdes; L Guillot-Noel; D A Akkad; P Blaschke; C Graetz; S Hoffjan; A Kroner; S Demir; A Böhme; P Rieckmann; A ElAli; N Hagemann; D M Hermann; I Cournu-Rebeix; F Zipp; T Kümpfel; M Buttmann; U K Zettl; B Fontaine; L Bertram; R Gold; A Chan
Journal:  J Neuroinflammation       Date:  2015-12-16       Impact factor: 8.322
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