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Literature DB >> 23858327

Sex and gender issues in multiple sclerosis.

Abstract

Multiple sclerosis (MS) is universally found to be more prevalent in women than men. This has led to extensive studies of differences in the immune system or nervous system between women and men, which might be caused by the effects of gonadal hormones, genetic differences, and different environmental exposures and modern lifestyle in men and women. We review the effects of sex and gender from a genetic, immunological and clinical point of view. We discuss the effects of sex on the clinical expression of MS and responses to therapy, as well as issues concerning pregnancy.

Entities: Disease Species

Keywords: Multiple sclerosis; female; genes; immunology; pregnancy; sex

Year: 2013 PMID： 23858327 PMCID： PMC3707353 DOI： 10.1177/1756285613488434

Source DB: PubMed Journal: Ther Adv Neurol Disord ISSN： 1756-2856 Impact factor: 6.570

103 in total

1. Offspring number, pregnancy, and risk of a first clinical demyelinating event: the AusImmune Study.

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Journal: Neurology Date: 2012-03-07 Impact factor: 9.910

Review 2. Epstein-barr virus infection and multiple sclerosis: a review.

Authors: Alberto Ascherio; Kassandra L Munger
Journal: J Neuroimmune Pharmacol Date: 2010-04-06 Impact factor: 4.147

3. Month of birth is associated with multiple sclerosis but not with HLA-DR15 in Finland.

Authors: Kari-Pekka Saastamoinen; Marja-Kaisa Auvinen; Pentti J Tienari
Journal: Mult Scler Date: 2011-10-31 Impact factor: 6.312

Review 4. Sex hormones in experimental autoimmune encephalomyelitis: implications for multiple sclerosis.

Authors: R R Voskuhl; K Palaszynski
Journal: Neuroscientist Date: 2001-06 Impact factor: 7.519

Review 5. Microchimerism in autoimmunity and transplantation: potential relevance to multiple sclerosis.

Authors: Cristen J Willer; A Dessa Sadovnick; George C Ebers
Journal: J Neuroimmunol Date: 2002-05 Impact factor: 3.478

6. Low maternal exposure to ultraviolet radiation in pregnancy, month of birth, and risk of multiple sclerosis in offspring: longitudinal analysis.

Authors: Judith Staples; Anne-Louise Ponsonby; Lynette Lim
Journal: BMJ Date: 2010-04-29

7. Cutting edge: the Y chromosome controls the age-dependent experimental allergic encephalomyelitis sexual dimorphism in SJL/J mice.

Authors: Karen M Spach; Melissa Blake; Janice Y Bunn; Ben McElvany; Rajkumar Noubade; Elizabeth P Blankenhorn; Cory Teuscher
Journal: J Immunol Date: 2009-02-15 Impact factor: 5.422

8. Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.

Authors: Stephen Sawcer; Garrett Hellenthal; Matti Pirinen; Chris C A Spencer; Nikolaos A Patsopoulos; Loukas Moutsianas; Alexander Dilthey; Zhan Su; Colin Freeman; Sarah E Hunt; Sarah Edkins; Emma Gray; David R Booth; Simon C Potter; An Goris; Gavin Band; Annette Bang Oturai; Amy Strange; Janna Saarela; Céline Bellenguez; Bertrand Fontaine; Matthew Gillman; Bernhard Hemmer; Rhian Gwilliam; Frauke Zipp; Alagurevathi Jayakumar; Roland Martin; Stephen Leslie; Stanley Hawkins; Eleni Giannoulatou; Sandra D'alfonso; Hannah Blackburn; Filippo Martinelli Boneschi; Jennifer Liddle; Hanne F Harbo; Marc L Perez; Anne Spurkland; Matthew J Waller; Marcin P Mycko; Michelle Ricketts; Manuel Comabella; Naomi Hammond; Ingrid Kockum; Owen T McCann; Maria Ban; Pamela Whittaker; Anu Kemppinen; Paul Weston; Clive Hawkins; Sara Widaa; John Zajicek; Serge Dronov; Neil Robertson; Suzannah J Bumpstead; Lisa F Barcellos; Rathi Ravindrarajah; Roby Abraham; Lars Alfredsson; Kristin Ardlie; Cristin Aubin; Amie Baker; Katharine Baker; Sergio E Baranzini; Laura Bergamaschi; Roberto Bergamaschi; Allan Bernstein; Achim Berthele; Mike Boggild; Jonathan P Bradfield; David Brassat; Simon A Broadley; Dorothea Buck; Helmut Butzkueven; Ruggero Capra; William M Carroll; Paola Cavalla; Elisabeth G Celius; Sabine Cepok; Rosetta Chiavacci; Françoise Clerget-Darpoux; Katleen Clysters; Giancarlo Comi; Mark Cossburn; Isabelle Cournu-Rebeix; Mathew B Cox; Wendy Cozen; Bruce A C Cree; Anne H Cross; Daniele Cusi; Mark J Daly; Emma Davis; Paul I W de Bakker; Marc Debouverie; Marie Beatrice D'hooghe; Katherine Dixon; Rita Dobosi; Bénédicte Dubois; David Ellinghaus; Irina Elovaara; Federica Esposito; Claire Fontenille; Simon Foote; Andre Franke; Daniela Galimberti; Angelo Ghezzi; Joseph Glessner; Refujia Gomez; Olivier Gout; Colin Graham; Struan F A Grant; Franca Rosa Guerini; Hakon Hakonarson; Per Hall; Anders Hamsten; Hans-Peter Hartung; Rob N Heard; Simon Heath; Jeremy Hobart; Muna Hoshi; Carmen Infante-Duarte; Gillian Ingram; Wendy Ingram; Talat Islam; Maja Jagodic; Michael Kabesch; Allan G Kermode; Trevor J Kilpatrick; Cecilia Kim; Norman Klopp; Keijo Koivisto; Malin Larsson; Mark Lathrop; Jeannette S Lechner-Scott; Maurizio A Leone; Virpi Leppä; Ulrika Liljedahl; Izaura Lima Bomfim; Robin R Lincoln; Jenny Link; Jianjun Liu; Aslaug R Lorentzen; Sara Lupoli; Fabio Macciardi; Thomas Mack; Mark Marriott; Vittorio Martinelli; Deborah Mason; Jacob L McCauley; Frank Mentch; Inger-Lise Mero; Tania Mihalova; Xavier Montalban; John Mottershead; Kjell-Morten Myhr; Paola Naldi; William Ollier; Alison Page; Aarno Palotie; Jean Pelletier; Laura Piccio; Trevor Pickersgill; Fredrik Piehl; Susan Pobywajlo; Hong L Quach; Patricia P Ramsay; Mauri Reunanen; Richard Reynolds; John D Rioux; Mariaemma Rodegher; Sabine Roesner; Justin P Rubio; Ina-Maria Rückert; Marco Salvetti; Erika Salvi; Adam Santaniello; Catherine A Schaefer; Stefan Schreiber; Christian Schulze; Rodney J Scott; Finn Sellebjerg; Krzysztof W Selmaj; David Sexton; Ling Shen; Brigid Simms-Acuna; Sheila Skidmore; Patrick M A Sleiman; Cathrine Smestad; Per Soelberg Sørensen; Helle Bach Søndergaard; Jim Stankovich; Richard C Strange; Anna-Maija Sulonen; Emilie Sundqvist; Ann-Christine Syvänen; Francesca Taddeo; Bruce Taylor; Jenefer M Blackwell; Pentti Tienari; Elvira Bramon; Ayman Tourbah; Matthew A Brown; Ewa Tronczynska; Juan P Casas; Niall Tubridy; Aiden Corvin; Jane Vickery; Janusz Jankowski; Pablo Villoslada; Hugh S Markus; Kai Wang; Christopher G Mathew; James Wason; Colin N A Palmer; H-Erich Wichmann; Robert Plomin; Ernest Willoughby; Anna Rautanen; Juliane Winkelmann; Michael Wittig; Richard C Trembath; Jacqueline Yaouanq; Ananth C Viswanathan; Haitao Zhang; Nicholas W Wood; Rebecca Zuvich; Panos Deloukas; Cordelia Langford; Audrey Duncanson; Jorge R Oksenberg; Margaret A Pericak-Vance; Jonathan L Haines; Tomas Olsson; Jan Hillert; Adrian J Ivinson; Philip L De Jager; Leena Peltonen; Graeme J Stewart; David A Hafler; Stephen L Hauser; Gil McVean; Peter Donnelly; Alastair Compston
Journal: Nature Date: 2011-08-10 Impact factor: 49.962

9. Geographical variations in sex ratio trends over time in multiple sclerosis.

Authors: Maria Trojano; Guglielmo Lucchese; Giusi Graziano; Bruce V Taylor; Steve Simpson; Vito Lepore; Francois Grand'maison; Pierre Duquette; Guillermo Izquierdo; Pierre Grammond; Maria Pia Amato; Roberto Bergamaschi; Giorgio Giuliani; Cavit Boz; Raymond Hupperts; Vincent Van Pesch; Jeannette Lechner-Scott; Edgardo Cristiano; Marcela Fiol; Celia Oreja-Guevara; Maria Laura Saladino; Freek Verheul; Mark Slee; Damiano Paolicelli; Carla Tortorella; Mariangela D'Onghia; Pietro Iaffaldano; Vita Direnzo; Helmut Butzkueven
Journal: PLoS One Date: 2012-10-25 Impact factor: 3.240

10. Importance of human leukocyte antigen (HLA) class I and II alleles on the risk of multiple sclerosis.

Authors: Jenny Link; Ingrid Kockum; Aslaug R Lorentzen; Benedicte A Lie; Elisabeth G Celius; Helga Westerlind; Marie Schaffer; Lars Alfredsson; Tomas Olsson; Boel Brynedal; Hanne F Harbo; Jan Hillert
Journal: PLoS One Date: 2012-05-07 Impact factor: 3.240

121 in total

1. A Systematic Review of Discrete-Choice Experiments and Conjoint Analysis Studies in People with Multiple Sclerosis.

Authors: Edward J D Webb; David Meads; Ieva Eskyte; Natalie King; Naila Dracup; Jeremy Chataway; Helen L Ford; Joachim Marti; Sue H Pavitt; Klaus Schmierer; Ana Manzano
Journal: Patient Date: 2018-08 Impact factor: 3.883

2. Effect of aerobic interval training on serum IL-10, TNFα, and adipokines levels in women with multiple sclerosis: possible relations with fatigue and quality of life.

Authors: Motahare Mokhtarzade; Rouholah Ranjbar; Nastaran Majdinasab; Darpan Patel; Mehdieh Molanouri Shamsi
Journal: Endocrine Date: 2017-06-14 Impact factor: 3.633

Review 3. Effects of the Menstrual Cycle on Neurological Disorders.

Authors: Hannah J Roeder; Enrique C Leira
Journal: Curr Neurol Neurosci Rep Date: 2021-05-10 Impact factor: 5.081

Review 4. The Pregnancy Pickle: Evolved Immune Compensation Due to Pregnancy Underlies Sex Differences in Human Diseases.

Authors: Heini Natri; Angela R Garcia; Kenneth H Buetow; Benjamin C Trumble; Melissa A Wilson
Journal: Trends Genet Date: 2019-07 Impact factor: 11.639