| Literature DB >> 15006410 |
Keith G Watson1, Rachel Cameron, Rob J Fenton, David Gower, Stephanie Hamilton, Betty Jin, Guy Y Krippner, Angela Luttick, Darryl McConnell, Simon J F MacDonald, Andy M Mason, Van Nguyen, Simon P Tucker, Wen-Yang Wu.
Abstract
A set of trimeric and tetrameric derivatives 6-11 of the influenza virus neuraminidase inhibitor zanamivir 1 have been synthesized by coupling a common monomeric zanamivir derivative 3 onto various multimeric carboxylic acid core groups. These discrete multimeric compounds are all significantly more antiviral than zanamivir and also show outstanding long-lasting protective activity when tested in mouse influenza infectivity experiments.Entities:
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Year: 2004 PMID： 15006410 DOI： 10.1016/j.bmcl.2003.09.102
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823