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Literature DB >> 22965667

A chemically programmed antibody is a long-lasting and potent inhibitor of influenza neuraminidase.

Masahiko Hayakawa¹, Narihiro Toda, Nancy Carrillo, Natalie J Thornburg, James E Crowe, Carlos F Barbas.

Abstract

Programming an anti-flu strategy: A new and potent neuraminidase inhibitor that maintains long-term systemic exposure of an antibody and the therapeutic activity of the neuraminadase inhibitor zanamivir has been created. This strategy could provide a promising new class of influenza A drugs for therapy and prophylaxis, and validates enzyme inhibitors as programming agents in synthetic immunology.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2012 PMID： 22965667 PMCID： PMC3517015 DOI： 10.1002/cbic.201200439

Source DB: PubMed Journal: Chembiochem ISSN： 1439-4227 Impact factor: 3.164

50 in total

Review 1. The war against influenza: discovery and development of sialidase inhibitors.

Authors: Mark von Itzstein
Journal: Nat Rev Drug Discov Date: 2007-12 Impact factor: 84.694

2. Instant immunity through chemically programmable vaccination and covalent self-assembly.

Authors: Mikhail Popkov; Beatriz Gonzalez; Subhash C Sinha; Carlos F Barbas
Journal: Proc Natl Acad Sci U S A Date: 2009-03-02 Impact factor: 11.205

3. Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic.

Authors: Gavin J D Smith; Dhanasekaran Vijaykrishna; Justin Bahl; Samantha J Lycett; Michael Worobey; Oliver G Pybus; Siu Kit Ma; Chung Lam Cheung; Jayna Raghwani; Samir Bhatt; J S Malik Peiris; Yi Guan; Andrew Rambaut
Journal: Nature Date: 2009-06-25 Impact factor: 49.962

4. Beta-lactam-based approach for the chemical programming of aldolase antibody 38C2.

Authors: Julia I Gavrilyuk; Ulrich Wuellner; Carlos F Barbas
Journal: Bioorg Med Chem Lett Date: 2009-01-15 Impact factor: 2.823

5. An efficient chemical approach to bispecific antibodies and antibodies of high valency.

Authors: Julia I Gavrilyuk; Ulrich Wuellner; Syed Salahuddin; Rajib K Goswami; Subhash C Sinha; Carlos F Barbas
Journal: Bioorg Med Chem Lett Date: 2009-05-18 Impact factor: 2.823

6. 4-Guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid is a highly effective inhibitor both of the sialidase (neuraminidase) and of growth of a wide range of influenza A and B viruses in vitro.

Authors: J M Woods; R C Bethell; J A Coates; N Healy; S A Hiscox; B A Pearson; D M Ryan; J Ticehurst; J Tilling; S M Walcott
Journal: Antimicrob Agents Chemother Date: 1993-07 Impact factor: 5.191

7. Emergence of a novel swine-origin influenza A (H1N1) virus in humans.

Authors: Fatimah S Dawood; Seema Jain; Lyn Finelli; Michael W Shaw; Stephen Lindstrom; Rebecca J Garten; Larisa V Gubareva; Xiyan Xu; Carolyn B Bridges; Timothy M Uyeki
Journal: N Engl J Med Date: 2009-05-07 Impact factor: 91.245

8. Synthesis and in vivo influenza virus-inhibitory effect of ester prodrug of 4-guanidino-7-O-methyl-Neu5Ac2en.

Authors: Takeshi Honda; Shuku Kubo; Takeshi Masuda; Masami Arai; Yoshiyuki Kobayashi; Makoto Yamashita
Journal: Bioorg Med Chem Lett Date: 2009-04-20 Impact factor: 2.823

9. Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humans.

Authors: Rebecca J Garten; C Todd Davis; Colin A Russell; Bo Shu; Stephen Lindstrom; Amanda Balish; Wendy M Sessions; Xiyan Xu; Eugene Skepner; Varough Deyde; Margaret Okomo-Adhiambo; Larisa Gubareva; John Barnes; Catherine B Smith; Shannon L Emery; Michael J Hillman; Pierre Rivailler; James Smagala; Miranda de Graaf; David F Burke; Ron A M Fouchier; Claudia Pappas; Celia M Alpuche-Aranda; Hugo López-Gatell; Hiram Olivera; Irma López; Christopher A Myers; Dennis Faix; Patrick J Blair; Cindy Yu; Kimberly M Keene; P David Dotson; David Boxrud; Anthony R Sambol; Syed H Abid; Kirsten St George; Tammy Bannerman; Amanda L Moore; David J Stringer; Patricia Blevins; Gail J Demmler-Harrison; Michele Ginsberg; Paula Kriner; Steve Waterman; Sandra Smole; Hugo F Guevara; Edward A Belongia; Patricia A Clark; Sara T Beatrice; Ruben Donis; Jacqueline Katz; Lyn Finelli; Carolyn B Bridges; Michael Shaw; Daniel B Jernigan; Timothy M Uyeki; Derek J Smith; Alexander I Klimov; Nancy J Cox
Journal: Science Date: 2009-05-22 Impact factor: 47.728

Review 10. Emergence and pandemic potential of swine-origin H1N1 influenza virus.

Authors: Gabriele Neumann; Takeshi Noda; Yoshihiro Kawaoka
Journal: Nature Date: 2009-06-18 Impact factor: 49.962

5 in total

1. Preparation and activities of macromolecule conjugates of the CCR5 antagonist Maraviroc.

Authors: Shigehiro Asano; Julia Gavrilyuk; Dennis R Burton; Carlos F Barbas
Journal: ACS Med Chem Lett Date: 2014-02-13 Impact factor: 4.345

Review 2. Chemically programmed antibodies.

Authors: Christoph Rader
Journal: Trends Biotechnol Date: 2014-03-11 Impact factor: 19.536